Selective diffusion changes of the visual pathways in patients with migraine: A 3-T tractography study

M. A. Rocca, E. Pagani, B. Colombo, P. Tortorella, A. Falini, G. Comi, M. Filippi

Research output: Contribution to journalArticle

Abstract

Using diffusion tensor (DT) tractography, we quantified optic radiation (OR) structural changes in seven migraine patients with (MA) and eight without visual aura (MoA) and their relation to clinical manifestations and T2-visible burden. The corticospinal tract and the corpus callosum were studied as 'control' white matter (WM). No difference was found for any of the WM fibre bundles metrics between controls and MoA patients. MA patients had reduced average fractional anisotropy (FA) of both OR compared with controls and reduced average FA of the right OR compared with MoA patients. They also showed higher right OR mean diffusivity than controls. OR metrics were not correlated with clinical and magnetic resonance imaging (MRI) metrics. DT tractography reveals OR changes in MA patients that might represent a phenotypic biomarker of the disease given the lack of correlation with clinical and structural MRI metrics.

Original languageEnglish
Pages (from-to)1061-1068
Number of pages8
JournalCephalalgia
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Aura
  • Migraine
  • Optic radiation
  • Tractography

ASJC Scopus subject areas

  • Clinical Neurology

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