Selective enrichment in human megakaryocyte progenitors by the B203.13 surface differentiation antigen

Marco Vitale, Giorgio Zauli, Alessandra Bassini, Giuseppe Visani, Rita Rezzani, Carlo M. Croce, Francesco Antonio Manzoli

Research output: Contribution to journalArticlepeer-review

Abstract

The B203.13 monoclonal antibody specifically recognizes a subset (8- 18.5%) of human CD34+ haemopoietic progenitors, which are significantly (P+/B203.13+ showed a greater number of cells/colony with respect to CD34+/B203.13-; (ii) after 10d of liquid cultures with 100ng/ml of thrombopoietin, only a minority of CD34-derived cells positive for CD41 coexpressed B203.13; (iii) in situ immunocytochemical staining revealed that B203.13 was expressed exclusively on immature megakaryoblasts; (iv) circulating platelets did not express B203.13.

Original languageEnglish
Pages (from-to)766-769
Number of pages4
JournalBritish Journal of Haematology
Volume99
Issue number4
Publication statusPublished - 1997

Keywords

  • Cell differentiation
  • Megakaryocytes
  • Platelets

ASJC Scopus subject areas

  • Hematology

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