The authors present the data relative to the immunological state of three children with a selective deficiency of IgA, one of which was an epileptic being treated with diphenylhydantoin. The clinical chart is characterized by recurrent infections of various apparatus (respiratory, urinary, gastrointestinal). Associated deficiency of IgD was present in two cases, normal or high concentration of serum IgE, decreased percentage of EAC rosettes in one case, antinuclear autoantibodies and smooth anti-musculature in another. In all three subjects the circulating lymphocytes with surface IgA were present in the normal percentage. In two cases the response to PHA and ConA was significantly low. On the basis of the clinical and laboratory data the authors conclude by making the hypothesis of a substantial immunological heterogeneity of the syndrome.
|Translated title of the contribution||Selective IgA deficiency and recurrent infections. (Immunological clinical study of three cases)|
|Number of pages||19|
|Publication status||Published - 1977|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health