Abstract
Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.
Original language | English |
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Pages (from-to) | 11656-11659 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 52 |
Issue number | 44 |
DOIs | |
Publication status | Published - Oct 25 2013 |
Keywords
- angiogenesis
- integrins
- peptidomimetics
- positron emission tomography
- RGD sequence
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis