Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3

Stefanie Neubauer, Florian Rechenmacher, Ambros J. Beer, Flavio Curnis, Karolin Pohle, Calogero D'Alessandria, Hans Jürgen Wester, Ute Reuning, Angelo Corti, Markus Schwaiger, Horst Kessler

Research output: Contribution to journalArticlepeer-review


Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.

Original languageEnglish
Pages (from-to)11656-11659
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number44
Publication statusPublished - Oct 25 2013


  • angiogenesis
  • integrins
  • peptidomimetics
  • positron emission tomography
  • RGD sequence

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis


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