Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3

Stefanie Neubauer; Florian Rechenmacher; Ambros J. Beer; Flavio Curnis; Karolin Pohle; Calogero D'Alessandria; Hans Jürgen Wester; Ute Reuning; Angelo Corti; Markus Schwaiger; Horst Kessler

doi:10.1002/anie.201306376

Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3

Stefanie Neubauer, Florian Rechenmacher, Ambros J. Beer, Flavio Curnis, Karolin Pohle, Calogero D'Alessandria, Hans Jürgen Wester, Ute Reuning, Angelo Corti, Markus Schwaiger, Horst Kessler

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.

Original language	English
Pages (from-to)	11656-11659
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	44
DOIs	https://doi.org/10.1002/anie.201306376
Publication status	Published - Oct 25 2013

Keywords

angiogenesis
integrins
peptidomimetics
positron emission tomography
RGD sequence

ASJC Scopus subject areas

Chemistry(all)
Catalysis

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Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3. / Neubauer, Stefanie; Rechenmacher, Florian; Beer, Ambros J.; Curnis, Flavio; Pohle, Karolin; D'Alessandria, Calogero; Wester, Hans Jürgen; Reuning, Ute; Corti, Angelo; Schwaiger, Markus; Kessler, Horst.

In: Angewandte Chemie - International Edition, Vol. 52, No. 44, 25.10.2013, p. 11656-11659.

Research output: Contribution to journal › Article › peer-review

Neubauer, Stefanie ; Rechenmacher, Florian ; Beer, Ambros J. ; Curnis, Flavio ; Pohle, Karolin ; D'Alessandria, Calogero ; Wester, Hans Jürgen ; Reuning, Ute ; Corti, Angelo ; Schwaiger, Markus ; Kessler, Horst. / Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 44. pp. 11656-11659.

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AU - Pohle, Karolin

AU - D'Alessandria, Calogero

AU - Wester, Hans Jürgen

AU - Reuning, Ute

AU - Corti, Angelo

AU - Schwaiger, Markus

AU - Kessler, Horst

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KW - peptidomimetics

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KW - RGD sequence

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Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3

Abstract

Keywords

ASJC Scopus subject areas

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