Selective increase of a subset of T cell receptor γδ T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection

A. De Maria, A. Ferrazin, S. Ferrini, E. Ciccone, A. Terragna, L. Moretta

Research output: Contribution to journalArticlepeer-review

Abstract

Increased proportions of the small lymphoid subset expressing T cell receptor (TCR) γδ occur in different infectious diseases, particularly in mycobacterial infections. In this study the two main subsets of TCR γδ+ cells in peripheral blood mononuclear cells (PBMC) of 54 patients with human immunodeficiency virus type 1 infection were analyzed. These subsets were defined by indirect immunofluorescence techniques and FACS analysis using BB3 and A13 monoclonal antibodies, which specifically react with Vδ2- and Vδ1- encoded forms of TCR γδ. The proportion of BB3+(Vδ2+) and A13+(Vδ1+) cells was analyzed in purified PBMC populations. Patients were stratified according to Walter Reed (WR) clinical stage. A sharp increase in percentage of A13+(Vδ1+) cells was observed in all stages of the disease. In addition, a strict correlation was found with stage of the disease and percentage of CD8+ PBMC. An inverse correlation was found with the proportion of CD4+ PBMC. An early (WR2) inversion of the Vδ2-to-Vδ1 ratio was consistently detected even before the inversion of the CD4-to-CD8 ratio.

Original languageEnglish
Pages (from-to)917-919
Number of pages3
JournalJournal of Infectious Diseases
Volume165
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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