Selective lesion of the nigrostriatal dopaminergic pathway by MPTP and acetaldehydehyde or diethyldithiocarbamate

Alessandro Zuddas, Francesca Vaglini, Francesco Fornai, Giovanni U. Corsini

Research output: Contribution to journalArticle

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Abstract

We have previously reported that diethyldithiocarbamate and acetaldehyde enhance MPTP toxicity in mice (Corsini et al. 1986). Here we show that these drugs enhance the depletion of dopamine in the striatum and markedly increase MPTP-induced death of DA neurons in the substantia nigra. This enhancement of MPTP toxicity is specific for the nigro-striatal DA pathway and no recovery occurs, at least for four months after the treatment. Rats, although they show an MPTP-induced acute syndrome similar to the that induced in mice by the combined treatments, appear to be insensitive to both MPTP alone or to combined treatment with diethyldithiocarbamate or acetaldehyde. The selectivity of the permanent bilateral lesions of the nigrostriatal pathway make mice treated with acetaldehyde or diethyldithiocarbamate and MPTP a simple and reliable model for parkinsonism.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalNeurochemistry International
Volume20
Issue numberSUPPL.
DOIs
Publication statusPublished - 1992

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Ditiocarb
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Acetaldehyde
Corpus Striatum
Parkinsonian Disorders
Substantia Nigra
Dopamine
Therapeutics
Neurons
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Selective lesion of the nigrostriatal dopaminergic pathway by MPTP and acetaldehydehyde or diethyldithiocarbamate. / Zuddas, Alessandro; Vaglini, Francesca; Fornai, Francesco; Corsini, Giovanni U.

In: Neurochemistry International, Vol. 20, No. SUPPL., 1992, p. 287-293.

Research output: Contribution to journalArticle

Zuddas, Alessandro ; Vaglini, Francesca ; Fornai, Francesco ; Corsini, Giovanni U. / Selective lesion of the nigrostriatal dopaminergic pathway by MPTP and acetaldehydehyde or diethyldithiocarbamate. In: Neurochemistry International. 1992 ; Vol. 20, No. SUPPL. pp. 287-293.
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