Selective motor imagery defect in patients with locked-in syndrome

Massimiliano Conson, Simona Sacco, Marco Sarà, Francesca Pistoia, Dario Grossi, Luigi Trojano

Research output: Contribution to journalArticle

Abstract

Recent studies indicate that motor imagery is subserved by activation of motor information. However, at present it is not clear whether the sparing of motor efferent pathways is necessary to perform a motor imagery task. To clarify this issue, we required patients with a selective, severe de-efferentation (locked-in syndrome, LIS) to mentally manipulate hands and three-dimensional objects. Compared with normal controls, LIS patients showed a profound impairment on a modified version of the hand-laterality task and a normal performance on mental rotation of abstract items. Moreover, LIS patients did not present visuomotor compatibility effects between anatomical side of hands and spatial location of stimuli on the computer screen. Such findings confirmed that the motor system is involved in mental simulation of action but not in mental manipulation of visual images. To explain LIS patients' inability in manipulating hand representations, we suggested that the pontine lesion, both determined a complete de-efferentation, and affected a component of the motor system, which is crucial for mental representation of body parts, probably the neural connections between parietal lobes and cerebellum.

Original languageEnglish
Pages (from-to)2622-2628
Number of pages7
JournalNeuropsychologia
Volume46
Issue number11
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Cerebellum
  • Locked-in syndrome
  • Mental rotation
  • Motor imagery
  • Motor system

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

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  • Cite this

    Conson, M., Sacco, S., Sarà, M., Pistoia, F., Grossi, D., & Trojano, L. (2008). Selective motor imagery defect in patients with locked-in syndrome. Neuropsychologia, 46(11), 2622-2628. https://doi.org/10.1016/j.neuropsychologia.2008.04.015