Selective oestrogen receptor modulators in prevention of breast cancer: An updated meta-analysis of individual participant data

Jack Cuzick, Ivana Sestak, Bernardo Bonanni, Joseph P. Costantino, Steve Cummings, Andrea DeCensi, Mitch Dowsett, John F. Forbes, Leslie Ford, Andrea Z. LaCroix, John Mershon, Bruce H. Mitlak, Trevor Powles, Umberto Veronesi, Victor Vogel, D. Lawrence Wickerham

Research output: Contribution to journalArticle

Abstract

Background Tamoxifen and raloxifene reduce the risk of breast cancer in women at elevated risk of disease, but the duration of the effect is unknown. We assessed the effectiveness of selective oestrogen receptor modulators (SERMs) on breast cancer incidence. Methods We did a meta-analysis with individual participant data from nine prevention trials comparing four selective oestrogen receptor modulators (SERMs; tamoxifen, raloxifene, arzoxifene, and lasofoxifene) with placebo, or in one study with tamoxifen. Our primary endpoint was incidence of all breast cancer (including ductal carcinoma in situ) during a 10 year follow-up period. Analysis was by intention to treat. Results We analysed data for 83 399 women with 306 617 women-years of follow-up. Median follow-up was 65 months (IQR 54-93). Overall, we noted a 38% reduction (hazard ratio [HR] 0·62, 95% CI 0·56-0·69) in breast cancer incidence, and 42 women would need to be treated to prevent one breast cancer event in the first 10 years of follow-up. The reduction was larger in the first 5 years of follow-up than in years 5-10 (42%, HR 0·58, 0·51-0·66; p

Original languageEnglish
Pages (from-to)1827-1834
Number of pages8
JournalLancet
Volume381
Issue number9880
DOIs
Publication statusPublished - 2013

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cuzick, J., Sestak, I., Bonanni, B., Costantino, J. P., Cummings, S., DeCensi, A., Dowsett, M., Forbes, J. F., Ford, L., LaCroix, A. Z., Mershon, J., Mitlak, B. H., Powles, T., Veronesi, U., Vogel, V., & Wickerham, D. L. (2013). Selective oestrogen receptor modulators in prevention of breast cancer: An updated meta-analysis of individual participant data. Lancet, 381(9880), 1827-1834. https://doi.org/10.1016/S0140-6736(13)60140-3