Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea

Krzysztof Narkiewicz, Philippe J H Van De Borne, Catherine A. Pesek, Mark E. Dyken, Nicola Montano, Virend K. Somers

Research output: Contribution to journalArticle

Abstract

Background - The chemoreflexes are an important mechanism for regulation of both breathing and autonomic cardiovascular function. Abnormalities in chemoreflex mechanisms may be implicated in increased cardiovascular stress in patients with obstructive sleep apnea (OSA). We tested the hypothesis that chemoreflex function is altered in patients with OSA. Methods and Results - We compared ventilatory, sympathetic, heart rate, and blood pressure responses to hypoxia, hypercapnia, and the cold pressor test in 16 untreated normotensive patients with OSA and 12 normal control subjects matched for age and body mass index. Baseline muscle sympathetic nerve activity (MSNA) was higher in the patients with OSA than in the control subjects (43±4 versus 21±3 bursts per minute; P

Original languageEnglish
Pages (from-to)1183-1189
Number of pages7
JournalCirculation
Volume99
Issue number9
Publication statusPublished - Mar 9 1999

Keywords

  • Blood pressure
  • Heart rate
  • Hypoxia
  • Nervous system
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Narkiewicz, K., Van De Borne, P. J. H., Pesek, C. A., Dyken, M. E., Montano, N., & Somers, V. K. (1999). Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation, 99(9), 1183-1189.