Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD)

A systematic review of randomized clinical trials

Franco De Crescenzo, Federica Perelli, Marco Armando, Stefano Vicari

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background The treatment of postpartum depression with selective serotonin reuptake inhibitors (SSRIs) has been claimed to be both efficacious and well tolerated, but no recent systematic reviews have been conducted. Methods A qualitative systematic review of randomized clinical trials on women with postpartum depression comparing SSRIs to placebo and/or other treatments was performed. A comprehensive literature search of online databases, the bibliographies of published articles and grey literature were conducted. Data on efficacy, acceptability and tolerability were extracted and the quality of the trials was assessed. Results Six randomised clinical trials, comprising 595 patients, met quality criteria for inclusion in the analysis. Cognitive-behavioural intervention, psychosocial community-based intervention, psychodynamic therapy, cognitive behavioural therapy, a second-generation tricyclic antidepressant and placebo were used as comparisons. All studies demonstrated higher response and remission rates among those treated with SSRIs and greater mean changes on depression scales, although findings were not always statistically significant. Dropout rates were high in three of the trials but similar among treatment and comparison groups. In general, SSRIs were well tolerated and trial quality was good. Limitations There are few trials, patients included in the trials were not representative of all patients with postpartum depression, dropout rates in three trials were high, and long-term efficacy and tolerability were assessed in only two trials. Conclusions SSRIs appear to be efficacious and well tolerated in the treatment of postpartum depression, but the available evidence fails to demonstrate a clear superiority over other treatments.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Affective Disorders
Volume152-154
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Postpartum Depression
Serotonin Uptake Inhibitors
Randomized Controlled Trials
Therapeutics
Placebos
Literature
Patient Advocacy
Tricyclic Antidepressive Agents
Bibliography
Cognitive Therapy
Databases
Depression

Keywords

  • Depression
  • Postpartum
  • Serotonin uptake inhibitors
  • Systematic review

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine(all)

Cite this

Selective serotonin reuptake inhibitors (SSRIs) for post-partum depression (PPD) : A systematic review of randomized clinical trials. / De Crescenzo, Franco; Perelli, Federica; Armando, Marco; Vicari, Stefano.

In: Journal of Affective Disorders, Vol. 152-154, No. 1, 01.2014, p. 39-44.

Research output: Contribution to journalArticle

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