Abstract
Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
| Original language | English |
|---|---|
| Pages (from-to) | 608-612 |
| Number of pages | 5 |
| Journal | Journal of Nutrition, Health and Aging |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1 2018 |
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Keywords
- frail elderly
- mortality
- Selenium
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Geriatrics and Gerontology
Cite this
Selenium Concentrations and Mortality Among Community-Dwelling Older Adults : Results from ilSIRENTE Study. / Giovannini, Silvia; Onder, G.; Lattanzio, F.; Bustacchini, S.; di Stefano, G.; Moresi, R.; Russo, A.; Bernabei, R.; Landi, F.
In: Journal of Nutrition, Health and Aging, Vol. 22, No. 5, 01.05.2018, p. 608-612.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selenium Concentrations and Mortality Among Community-Dwelling Older Adults
T2 - Results from ilSIRENTE Study
AU - Giovannini, Silvia
AU - Onder, G.
AU - Lattanzio, F.
AU - Bustacchini, S.
AU - di Stefano, G.
AU - Moresi, R.
AU - Russo, A.
AU - Bernabei, R.
AU - Landi, F.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
AB - Background: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. Objectives: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. Design and Setting: Data are from the ‘Invecchiamento e Longevità nel Sirente’ (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up. Participants and measurements: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium. Results: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92). Conclusions: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
KW - frail elderly
KW - mortality
KW - Selenium
UR - http://www.scopus.com/inward/record.url?scp=85044218223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044218223&partnerID=8YFLogxK
U2 - 10.1007/s12603-018-1021-9
DO - 10.1007/s12603-018-1021-9
M3 - Article
AN - SCOPUS:85044218223
VL - 22
SP - 608
EP - 612
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
SN - 1279-7707
IS - 5
ER -