Abstract
BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.
OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.
DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.
PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.
RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).
CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
| Original language | English |
|---|---|
| Pages (from-to) | 608-612 |
| Number of pages | 5 |
| Journal | Journal of Nutrition, Health and Aging |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 |
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Selenium Concentrations and Mortality among Community-Dwelling Older Adults : Results from IlSIRENTE Study. / Giovannini, S; Onder, G; Lattanzio, F; Bustacchini, S; Di Stefano, G; Moresi, R; Russo, A; Bernabei, R; Landi, F.
In: Journal of Nutrition, Health and Aging, Vol. 22, No. 5, 2018, p. 608-612.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selenium Concentrations and Mortality among Community-Dwelling Older Adults
T2 - Results from IlSIRENTE Study
AU - Giovannini, S
AU - Onder, G
AU - Lattanzio, F
AU - Bustacchini, S
AU - Di Stefano, G
AU - Moresi, R
AU - Russo, A
AU - Bernabei, R
AU - Landi, F
PY - 2018
Y1 - 2018
N2 - BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
AB - BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.
U2 - 10.1007/s12603-018-1021-9
DO - 10.1007/s12603-018-1021-9
M3 - Article
C2 - 29717761
VL - 22
SP - 608
EP - 612
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
SN - 1279-7707
IS - 5
ER -