Selenium Concentrations and Mortality among Community-Dwelling Older Adults: Results from IlSIRENTE Study

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Abstract

BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.

OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.

DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.

PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.

RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).

CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.

Original languageEnglish
Pages (from-to)608-612
Number of pages5
JournalJournal of Nutrition, Health and Aging
Volume22
Issue number5
DOIs
Publication statusPublished - 2018

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Independent Living
Selenium
Mortality
Serum
Thyroid Hormones
Oxidation-Reduction
Oxidative Stress
Homeostasis
Cohort Studies
Prospective Studies
Inflammation

Cite this

@article{0a94a36a89bf46cf81e4c4c0cdfd327c,
title = "Selenium Concentrations and Mortality among Community-Dwelling Older Adults: Results from IlSIRENTE Study",
abstract = "BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevit{\`a} nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95{\%} CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95{\%} CI 0.54-0.92).CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.",
author = "S Giovannini and G Onder and F Lattanzio and S Bustacchini and {Di Stefano}, G and R Moresi and A Russo and R Bernabei and F Landi",
year = "2018",
doi = "10.1007/s12603-018-1021-9",
language = "English",
volume = "22",
pages = "608--612",
journal = "Journal of Nutrition, Health and Aging",
issn = "1279-7707",
publisher = "Springer Paris",
number = "5",

}

TY - JOUR

T1 - Selenium Concentrations and Mortality among Community-Dwelling Older Adults

T2 - Results from IlSIRENTE Study

AU - Giovannini, S

AU - Onder, G

AU - Lattanzio, F

AU - Bustacchini, S

AU - Di Stefano, G

AU - Moresi, R

AU - Russo, A

AU - Bernabei, R

AU - Landi, F

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.

AB - BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.PARTICIPANTS AND MEASUREMENTS: Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.RESULTS: A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).CONCLUSIONS: Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.

U2 - 10.1007/s12603-018-1021-9

DO - 10.1007/s12603-018-1021-9

M3 - Article

C2 - 29717761

VL - 22

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EP - 612

JO - Journal of Nutrition, Health and Aging

JF - Journal of Nutrition, Health and Aging

SN - 1279-7707

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ER -