Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study

Ilenia Pirola, Mario Rotondi, Alessandra Cristiano, Filippo Maffezzoni, Daniela Pasquali, Fiorella Marini, Francesca Coperchini, Matteo Paganelli, Pietro Apostoli, Luca Chiovato, Alberto Ferlin, Carlo Cappelli

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The purpose of this prospective study was to assess the effects of selenium supplementation on TSH and interferon-γ inducible chemokines (CXCL9, CXCL10 and CXCL11) levels in patients with subclinical hypothyroidism due to Hashimoto's thyroiditis.

PATIENTS AND METHODS: Patients with subclinical hypothyroidism due to Hashimoto thyroiditis were prospectively enrolled in the SETI study. They received 83mcg of selenomethionine/day orally in a soft gel capsule for 4 months with water after a meal. No further treatment was given. All patients were measured thyroid hormone, TPOAb, CXCL9, CXCL10, CXCL11, iodine, and selenium levels at baseline and at study end.

RESULTS: 50 patients (43/7 female/male, median age 43.9±11.8 years) were enrolled, of which five withdrew from the study. At the end of the study, euthyroidism was restored in 22/45 (48.9%) participants (responders), while 23 patients remained hypothyroid (non-responders). There were no significant changes in TPOAb, CXCL9, CXCL10, CXCL11, and iodine levels from baseline to the end of the study in both responders and non-responders. TSH levels were re-tested six months after selenomethionine withdrawal: 83.3% of responding patients remained euthyroid, while only 14.2% of non-responders became euthyroid.

CONCLUSIONS: The SETI study shows that short-course supplementation with selenomethionine is associated to a normalization of serum TSH levels which is maintained 6 months after selenium withdrawal in 50% of patients with subclinical hypothyroidism due to chronic autoimmune thyroiditis. This TSH-lowering effect of selenium supplementation is unlikely to be related to changes in humoral markers of autoimmunity and/or circulating CXCL9.

Original languageEnglish
Pages (from-to)28-35
Number of pages8
JournalEndocrinologia, Diabetes y Nutricion
Issue number1
Publication statusPublished - Jan 2020


  • Administration, Oral
  • Adult
  • Aged
  • Analysis of Variance
  • Antibodies/blood
  • Autoantigens/immunology
  • Chemokine CXCL10/blood
  • Chemokine CXCL11/blood
  • Chemokine CXCL2/blood
  • Female
  • Hashimoto Disease/blood
  • Humans
  • Hypothyroidism/blood
  • Interferon-gamma
  • Iodide Peroxidase/immunology
  • Iodine/blood
  • Iron-Binding Proteins/immunology
  • Logistic Models
  • Male
  • Middle Aged
  • Prospective Studies
  • ROC Curve
  • Selenium/blood
  • Selenomethionine/administration & dosage
  • Thyrotropin/blood
  • Treatment Outcome
  • Young Adult


Dive into the research topics of 'Selenium supplementation in patients with subclinical hypothyroidism affected by autoimmune thyroiditis: Results of the SETI study'. Together they form a unique fingerprint.

Cite this