Abstract
Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.
| Original language | English |
|---|---|
| Pages (from-to) | 401-407 |
| Number of pages | 7 |
| Journal | American Journal of Alzheimer's Disease and other Dementias |
| Volume | 32 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Nov 1 2017 |
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Keywords
- Alzheimer's disease
- anosognosia
- awareness
- dementia
- mild cognitive impairment
ASJC Scopus subject areas
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment : A Longitudinal Study. / Cova, Ilaria; Grande, Giulia; Cucumo, Valentina; Ghiretti, Roberta; Maggiore, Laura; Galimberti, Daniela; Scarpini, Elio; Mariani, Claudio; Pomati, Simone.
In: American Journal of Alzheimer's Disease and other Dementias, Vol. 32, No. 7, 01.11.2017, p. 401-407.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment
T2 - A Longitudinal Study
AU - Cova, Ilaria
AU - Grande, Giulia
AU - Cucumo, Valentina
AU - Ghiretti, Roberta
AU - Maggiore, Laura
AU - Galimberti, Daniela
AU - Scarpini, Elio
AU - Mariani, Claudio
AU - Pomati, Simone
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.
AB - Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.
KW - Alzheimer's disease
KW - anosognosia
KW - awareness
KW - dementia
KW - mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=85030849525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030849525&partnerID=8YFLogxK
U2 - 10.1177/1533317517725812
DO - 10.1177/1533317517725812
M3 - Article
AN - SCOPUS:85030849525
VL - 32
SP - 401
EP - 407
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
SN - 1533-3175
IS - 7
ER -