Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment: A Longitudinal Study

Ilaria Cova, Giulia Grande, Valentina Cucumo, Roberta Ghiretti, Laura Maggiore, Daniela Galimberti, Elio Scarpini, Claudio Mariani, Simone Pomati

Research output: Contribution to journalArticle

Abstract

Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume32
Issue number7
DOIs
Publication statusPublished - Nov 1 2017

Fingerprint

Longitudinal Studies
Dementia
Alzheimer Disease
Geriatrics
Depression
Agnosia
Sex Education
Memory Disorders
Apolipoproteins E
Proportional Hazards Models
Multivariate Analysis
Genotype
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • anosognosia
  • awareness
  • dementia
  • mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment : A Longitudinal Study. / Cova, Ilaria; Grande, Giulia; Cucumo, Valentina; Ghiretti, Roberta; Maggiore, Laura; Galimberti, Daniela; Scarpini, Elio; Mariani, Claudio; Pomati, Simone.

In: American Journal of Alzheimer's Disease and other Dementias, Vol. 32, No. 7, 01.11.2017, p. 401-407.

Research output: Contribution to journalArticle

Cova, Ilaria ; Grande, Giulia ; Cucumo, Valentina ; Ghiretti, Roberta ; Maggiore, Laura ; Galimberti, Daniela ; Scarpini, Elio ; Mariani, Claudio ; Pomati, Simone. / Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment : A Longitudinal Study. In: American Journal of Alzheimer's Disease and other Dementias. 2017 ; Vol. 32, No. 7. pp. 401-407.
@article{2585dd26b2d34c6db30c3b07a4a1bb9a,
title = "Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment: A Longitudinal Study",
abstract = "Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3{\%}) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.",
keywords = "Alzheimer's disease, anosognosia, awareness, dementia, mild cognitive impairment",
author = "Ilaria Cova and Giulia Grande and Valentina Cucumo and Roberta Ghiretti and Laura Maggiore and Daniela Galimberti and Elio Scarpini and Claudio Mariani and Simone Pomati",
year = "2017",
month = "11",
day = "1",
doi = "10.1177/1533317517725812",
language = "English",
volume = "32",
pages = "401--407",
journal = "American Journal of Alzheimer's Disease and other Dementias",
issn = "1533-3175",
publisher = "SAGE Publications Inc.",
number = "7",

}

TY - JOUR

T1 - Self-Awareness for Memory Impairment in Amnestic Mild Cognitive Impairment

T2 - A Longitudinal Study

AU - Cova, Ilaria

AU - Grande, Giulia

AU - Cucumo, Valentina

AU - Ghiretti, Roberta

AU - Maggiore, Laura

AU - Galimberti, Daniela

AU - Scarpini, Elio

AU - Mariani, Claudio

AU - Pomati, Simone

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.

AB - Aim: To assess memory impairment insight as a predictor of dementia and Alzheimer's disease (AD) in amnestic mild cognitive impairment (MCI). Methods: To verify whether the awareness of memory impairment assessed by Geriatric Depression Scale (GDS) was associated with the risk of progression to dementia and AD in a cohort of MCI, we used a Cox regression model adjusted for age, sex, education, subtypes of amnestic MCI, Mini-Mental State Examination, Cumulative Illness Rating Scale severity index, and apolipoprotein E genotype. Results: During a follow-up of 27.7 (20.8) months, 205 (63.3%) of 324 patients with amnestic MCI progressed to dementia, including 141 to AD. No association was found in the unadjusted, partially adjusted (for sociodemographic variables), and fully adjusted multivariate Cox analysis between the awareness of memory impairment and the progression to dementia and AD. Discussion: Awareness or anosognosia of memory deficits, identified by GDS, is not useful to predict progression to dementia of patients with amnestic MCI.

KW - Alzheimer's disease

KW - anosognosia

KW - awareness

KW - dementia

KW - mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=85030849525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030849525&partnerID=8YFLogxK

U2 - 10.1177/1533317517725812

DO - 10.1177/1533317517725812

M3 - Article

AN - SCOPUS:85030849525

VL - 32

SP - 401

EP - 407

JO - American Journal of Alzheimer's Disease and other Dementias

JF - American Journal of Alzheimer's Disease and other Dementias

SN - 1533-3175

IS - 7

ER -