Self-closing nitinol U-Clips for intracranial arterial microanastomosis: A preliminary experience on seven cases

P. Ferroli, F. Acerbi, G. Tringali, G. Polvani, E. Parati, G. Broggi

Research output: Contribution to journalArticlepeer-review


Purpose: To report experience on the use of self-closing nitinol U-Clips for different types of intracranial arterial microanastomosis. Methods: We treated 7 patients (3 females and 4 males, age ranging from 25 to 68 yo) admitted from November 2005 to January 2008 to the Neurological Institute C. Besta of Milan. One patient had cerebral hypoperfusion and the others a complex intracranial aneurysm. In each patient a bypass procedure was completed by using self-closing Nitinol U-Clips for intracranial arterial microanastomoses. Results: The total time of temporary occlusion was 15.71±4.386 min. Bypass patency was confirmed intraoperatively by near-infrared indocyanine green videoangiography and microdoppler in each patient. No spasm of the graft was encountered and immediate post-operative bypass patency was confirmed in 6/7 patients. The graft thrombosed in 1 patient with antiphospholipid syndrome. 1 patient died from a massive Subarachnoid Hemorrhage due to rupture of an aneurysm while waiting for an endovascular procedure. In the 5 patients at the last follow-up, long-term patency of the bypass was confirmed and no neurological deficits occurred related to the procedure. Conclusion: This is the first report of the use of U-Clips for intracranial microanastomosis. Our data indicated that it is a safe technique, reduces the time taken to perform an anastomosis and the risk of an ischemic complication. Further studies of the longer-term patency of bypass as performed with U-Clips are required.

Original languageEnglish
Pages (from-to)969-976
Number of pages8
JournalActa Neurochirurgica
Issue number8
Publication statusPublished - Aug 2009


  • Arterial microanastomoses
  • Cerebral aneurysm
  • Intracranial bypass
  • UClip

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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