Self-esteem in remitted patients with mood disorders is not associated with the dopamine receptor D4 and the serotonin transporter genes

Alessandro Serretti, Fabio Macciardi, Daniela Di Bella, Marco Catalano, Enrico Smeraldi

Research output: Contribution to journalArticle

Abstract

Disturbances of the dopaminergic and serotoninergic neurotransmitter systems have been implicated in the pathogenesis of depressive symptoms. Associations have been reported between markers of the two neurotransmitter systems and the presence of illness or severity of depressive episodes, but no attention has been focused on the periods of remission. The present report focuses on a possible association of self-esteem in remitted mood disorder patients with the functional polymorphism located in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) and the dopamine receptor D4 (DRD4). Inpatients (N = 162) affected by bipolar (n = 103) and unipolar (n = 59) disorder (DSM III-R) were assessed by the Self-Esteem Scale (SES, Rosenberg, 1965) and were typed for DRD4 and 5-HTTLPR (n = 58 subjects) variants at the third exon using polymerase chain reaction (PCR) techniques. Neither DRD4 nor 5-HTTLPR variants were associated with SES scores, and consideration of possible stratification effects such as sex and psychiatric diagnosis did not reveal any association either. The serotonin transporter and dopamine receptor D4 genes do not, therefore, influence self-esteem in remitted mood disorder subjects.

Original languageEnglish
Pages (from-to)137-144
Number of pages8
JournalPsychiatry Research
Volume80
Issue number2
DOIs
Publication statusPublished - Aug 17 1998

Keywords

  • Bipolar disorder
  • Depressive disorder
  • Dopamine receptors
  • Genetics
  • Self esteem
  • Serotonin receptors

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Fingerprint Dive into the research topics of 'Self-esteem in remitted patients with mood disorders is not associated with the dopamine receptor D4 and the serotonin transporter genes'. Together they form a unique fingerprint.

  • Cite this