Self-expanding metal stenting for palliation of patients with malignant colonic obstruction

Effectiveness and efficacy on 255 patients with 12-month's follow-up

Søren Meisner, Ferran González-Huix, Jo G. Vandervoort, Alessandro Repici, Dimitrios Xinopoulos, Karl E. Grund, Paul Goldberg

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4 (251). Clinical success rates were 87.8 at 30 days, 89.7 at 3 months, 92.8 at 6 months, and 96 at 12 months. Overall perforation rate was 5.1. Overall migration rate was 5.5. Overall death rate during follow-up was 48.6 (124), with 67.7 of deaths related to the patient's colorectal cancer, unrelated in 32.3. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications.

Original languageEnglish
Article number296347
JournalGastroenterology Research and Practice
DOIs
Publication statusPublished - 2012

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Stents
Metals
Safety
Retreatment
Community Hospital
Palliative Care
Multicenter Studies
Small Intestine
Colorectal Neoplasms
Pathologic Constriction
Outcome Assessment (Health Care)
Control Groups
Mortality

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Self-expanding metal stenting for palliation of patients with malignant colonic obstruction : Effectiveness and efficacy on 255 patients with 12-month's follow-up. / Meisner, Søren; González-Huix, Ferran; Vandervoort, Jo G.; Repici, Alessandro; Xinopoulos, Dimitrios; Grund, Karl E.; Goldberg, Paul.

In: Gastroenterology Research and Practice, 2012.

Research output: Contribution to journalArticle

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abstract = "Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4 (251). Clinical success rates were 87.8 at 30 days, 89.7 at 3 months, 92.8 at 6 months, and 96 at 12 months. Overall perforation rate was 5.1. Overall migration rate was 5.5. Overall death rate during follow-up was 48.6 (124), with 67.7 of deaths related to the patient's colorectal cancer, unrelated in 32.3. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications.",
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AU - Vandervoort, Jo G.

AU - Repici, Alessandro

AU - Xinopoulos, Dimitrios

AU - Grund, Karl E.

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AB - Background. Self-expanding metal stents can alleviate malignant colonic obstruction in incurable patients and avoid palliative stoma surgery. Objective. Evaluate stent effectiveness and safety on palliation of patients with malignant colorectal strictures. Design. Two prospective, one Spanish and one global, multicenter studies. Settings. 39 centers (22 academic, 17 community hospitals) from 13 countries. Patients. A total of 257 patients were enrolled, and 255 patients were treated with a WallFlex uncovered enteral colonic stent. Follow-up was up to 12 months or until death or retreatment. Interventions(s). Self-expanding metal stent placement. Main Outcome Measures. Procedural success, clinical success, and safety. Results. Procedural success was 98.4 (251). Clinical success rates were 87.8 at 30 days, 89.7 at 3 months, 92.8 at 6 months, and 96 at 12 months. Overall perforation rate was 5.1. Overall migration rate was 5.5. Overall death rate during follow-up was 48.6 (124), with 67.7 of deaths related to the patient's colorectal cancer, unrelated in 32.3. Only 2 deaths were related to the stent or procedure. Limitations. No control group. Conclusions. The primary palliative option for patients with malignant colonic obstruction should be self-expanding metal stent placement due to high rates of technical success and efficacy in symptom palliation and few complications.

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