Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

D. Nardo, G. Högberg, F. Flumeri, H. Jacobsson, S. A. Larsson, T. Hällström, M. Pagani

Research output: Contribution to journalArticlepeer-review


Background The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related post-traumatic stress disorder (PTSD) subjects and to seek possible correlations between brain perfusion and self-rating scales (SRS) in order to cross-check their diagnostic value and to look for their neural correlates.Method A total of 13 traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD who had experienced a 'person under train' accident or who had been assaulted at work underwent clinical assessment and 99mTc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping was applied to analyse rCBF changes in S as compared with NS and to search for correlations between rCBF and the administered SRS scores, modelling age, months to SPECT and the ratio 'grey matter/intra-cranial volume' as nuisance variables.Results Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared with the trauma-exposed control group. Impact of Event Scale and World Health Organisation (10) Well-Being Index scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found.Conclusions These findings support the involvement of insular, cingulate and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.

Original languageEnglish
Pages (from-to)2549-2561
Number of pages13
JournalPsychological Medicine
Issue number12
Publication statusPublished - Dec 2011


  • Impact of Event Scale
  • PTSD
  • rCBF
  • subjective distress
  • subjective well-being
  • Well-Being Index

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Applied Psychology
  • Medicine(all)


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