Self-reported alteration of sense of smell or taste in patients with COVID-19: A systematic review and meta-analysis on 3563 patients

Daniele Borsetto, Claire Hopkins, Veronica Philips, Rupert Obholzer, Giancarlo Tirelli, Jerry Polesel, Paolo Boscolo-Rizzo

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Emerging reports suggest that new onset of smell or taste loss are potential early clinical markers of SARS-CoV-2 infection, but it remains unclear as to what extent. Therefore, the purpose of this study is to systematically assess the prevalence of self-reported altered sense of smell or taste in patients with confirmed SARS-CoV-2 infection, overcoming the limitations of individual studies by meta-analysis of pooled data. Methods: The databases Medline, Embase, Web of Science, Scopus and MedRxiv’s set were searched from inception to the 4th May 2020. This study was conducted following the PRISMA checklist. Results: 18 studies met the eligibility criteria out of the 171 initially screened citations. The overall prevalence of alteration of the sense of smell or taste was 47%, but estimates were 31% and 67% in severe and mild-to-moderate symptomatic patients, respectively. The loss of smell and taste preceded other symptoms in 20% of cases and it was concomitant in 28%. Conclusions: Based on this meta-analysis, we recommend self-isolation and testing, where possible, for patients complaining smell or taste impairment during COVID-19 pandemic in order to prevent spread of disease and propose the inclusion of loss of smell and taste as recognized symptoms of SARS-CoV-2 in the World Health Organization and other relevant regulatory body’s lists.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalRhinology
Volume58
Issue number5
DOIs
Publication statusPublished - 2020

Keywords

  • Ageusia
  • Anosmia
  • Covid-19
  • SARS-CoV-2
  • Smell loss
  • Taste loss

ASJC Scopus subject areas

  • Otorhinolaryngology

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