SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis

Chiara Fenoglio, Daniela Galimberti, Maria Ban, Mel Maranian, Diego Scalabrini, Eliana Venturelli, Laura Piccio, Milena De Riz, Tai Wai Yeo, An Goris, Julia Gray, Nereo Bresolin, Elio Scarpini, Alastair Compston, Stephen Sawcer

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

P-Selectin (SELP) and P-selectin glycoprotein ligand-1 (SELPLG) constitute a receptor/ligand complex involved in the recruitment of activated lymphocytes, a critical event in the pathogenesis of multiple sclerosis (MS). In order to determine whether genetic variation in these pivotal molecules influences susceptibility to MS, we genotyped 214 Italian patients compared with 220 Italian controls for three single-nucleotide polymorphisms (SNPs): SELPLG Met62Ile, SELP C-2123G and SELP Thr715Pro. No significant differences in both SELP SNPs were found between patients and controls, whereas a decreased frequency of the Met62Ile SNP was found in patients versus controls in the Italian population (P = 0.025). To confirm these preliminary findings, the Met62Ile SNP was analysed in 938 UK trio families. This SNP did not show evidence for association with susceptibility to MS in the larger UK cohort. Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested.

Original languageEnglish
Pages (from-to)92-96
Number of pages5
JournalNeuroscience Letters
Volume394
Issue number2
DOIs
Publication statusPublished - Feb 13 2006

Fingerprint

Multiple Sclerosis
Single Nucleotide Polymorphism
P-Selectin
P-selectin ligand protein
Lymphocytes
Ligands
Population

Keywords

  • Adhesion molecules
  • Multiple sclerosis
  • Polymorphism
  • SELP
  • SELPLG

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. / Fenoglio, Chiara; Galimberti, Daniela; Ban, Maria; Maranian, Mel; Scalabrini, Diego; Venturelli, Eliana; Piccio, Laura; De Riz, Milena; Yeo, Tai Wai; Goris, An; Gray, Julia; Bresolin, Nereo; Scarpini, Elio; Compston, Alastair; Sawcer, Stephen.

In: Neuroscience Letters, Vol. 394, No. 2, 13.02.2006, p. 92-96.

Research output: Contribution to journalArticle

Fenoglio, C, Galimberti, D, Ban, M, Maranian, M, Scalabrini, D, Venturelli, E, Piccio, L, De Riz, M, Yeo, TW, Goris, A, Gray, J, Bresolin, N, Scarpini, E, Compston, A & Sawcer, S 2006, 'SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis', Neuroscience Letters, vol. 394, no. 2, pp. 92-96. https://doi.org/10.1016/j.neulet.2005.10.014
Fenoglio, Chiara ; Galimberti, Daniela ; Ban, Maria ; Maranian, Mel ; Scalabrini, Diego ; Venturelli, Eliana ; Piccio, Laura ; De Riz, Milena ; Yeo, Tai Wai ; Goris, An ; Gray, Julia ; Bresolin, Nereo ; Scarpini, Elio ; Compston, Alastair ; Sawcer, Stephen. / SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis. In: Neuroscience Letters. 2006 ; Vol. 394, No. 2. pp. 92-96.
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