Semaphorin pathways orchestrate osteogenesis

Research output: Contribution to journalArticlepeer-review


Semaphorins regulate a variety of biological processes, including axon guidance, neuronal migration, angiogenesis, cardiogenesis and immune responses. Semaphorin 6D is now shown to regulate osteoclast function during bone development, through its association with its receptor plexinA1. This activity implicates a signalling pathway known to transcriptionally regulate cell differentiation and involves the receptor Trem2 and the adaptor DAP12.

Original languageEnglish
Pages (from-to)545-547
Number of pages3
JournalNature Cell Biology
Issue number6
Publication statusPublished - Jun 2006

ASJC Scopus subject areas

  • Cell Biology

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