Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment

Alessandra Retico, Graziella Donatelli, Mauro Costagli, Laura Biagi, Maria Evelina Fantacci, Daniela Frosini, Gloria Tognoni, Mirco Cosottini, Michela Tosetti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The current availability of Magnetic Resonance (MR) systems that operate at ultra high magnetic field (≥ 7 Tesla) allows the representation of anatomical structures at sub-millimeter resolution. Interestingly, small structures of the brain, such as the subfields of the hippocampus, the inner structures of the basal ganglia and of the brainstem become visible. Suitable software packages that allow analyzing and measuring such small structures are not currently readily available. We developed a semi-automated procedure to measure the thickness of the stratum radiatum and lacunosum-moleculare (SRLM) of the hippocampus. The change in the thickness of this subfield of the hippocampal formation is supposed to have a role in the pathological cognitive decline. Once we developed and validated the semiautomatic procedure on the 7T high-resolution T2∗-weighted images of a healthy volunteer, we carried out a preliminary study on a population affected by Mild Cognitive Impairment to investigate the correlations of the SRLM thickness with the clinical scores of the patients, e.g. the Mini-Mental State Examination score and the Free and Cued Selective Reminding Test.

Original languageEnglish
Title of host publicationBIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016
PublisherSciTePress
Pages124-128
Number of pages5
ISBN (Print)9789897581700
Publication statusPublished - 2016
Event3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 - Rome, Italy
Duration: Feb 21 2016Feb 23 2016

Other

Other3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016
CountryItaly
CityRome
Period2/21/162/23/16

Fingerprint

Magnetic resonance
Software packages
Brain
Image processing
Availability
Magnetic fields

Keywords

  • Alzheimer disease
  • Hippocampus
  • Image processing methods
  • Magnetic resonance imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering

Cite this

Retico, A., Donatelli, G., Costagli, M., Biagi, L., Fantacci, M. E., Frosini, D., ... Tosetti, M. (2016). Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. In BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 (pp. 124-128). SciTePress.

Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. / Retico, Alessandra; Donatelli, Graziella; Costagli, Mauro; Biagi, Laura; Fantacci, Maria Evelina; Frosini, Daniela; Tognoni, Gloria; Cosottini, Mirco; Tosetti, Michela.

BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016. SciTePress, 2016. p. 124-128.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Retico, A, Donatelli, G, Costagli, M, Biagi, L, Fantacci, ME, Frosini, D, Tognoni, G, Cosottini, M & Tosetti, M 2016, Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. in BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016. SciTePress, pp. 124-128, 3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016, Rome, Italy, 2/21/16.
Retico A, Donatelli G, Costagli M, Biagi L, Fantacci ME, Frosini D et al. Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. In BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016. SciTePress. 2016. p. 124-128
Retico, Alessandra ; Donatelli, Graziella ; Costagli, Mauro ; Biagi, Laura ; Fantacci, Maria Evelina ; Frosini, Daniela ; Tognoni, Gloria ; Cosottini, Mirco ; Tosetti, Michela. / Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016. SciTePress, 2016. pp. 124-128
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