Abstract
The current availability of Magnetic Resonance (MR) systems that operate at ultra high magnetic field (≥ 7 Tesla) allows the representation of anatomical structures at sub-millimeter resolution. Interestingly, small structures of the brain, such as the subfields of the hippocampus, the inner structures of the basal ganglia and of the brainstem become visible. Suitable software packages that allow analyzing and measuring such small structures are not currently readily available. We developed a semi-automated procedure to measure the thickness of the stratum radiatum and lacunosum-moleculare (SRLM) of the hippocampus. The change in the thickness of this subfield of the hippocampal formation is supposed to have a role in the pathological cognitive decline. Once we developed and validated the semiautomatic procedure on the 7T high-resolution T2∗-weighted images of a healthy volunteer, we carried out a preliminary study on a population affected by Mild Cognitive Impairment to investigate the correlations of the SRLM thickness with the clinical scores of the patients, e.g. the Mini-Mental State Examination score and the Free and Cued Selective Reminding Test.
| Original language | English |
|---|---|
| Title of host publication | BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 |
| Publisher | SciTePress |
| Pages | 124-128 |
| Number of pages | 5 |
| ISBN (Print) | 9789897581700 |
| Publication status | Published - 2016 |
| Event | 3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 - Rome, Italy Duration: Feb 21 2016 → Feb 23 2016 |
Other
| Other | 3rd International Conference on Bioimaging, BIOIMAGING 2016 - Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016 |
|---|---|
| Country | Italy |
| City | Rome |
| Period | 2/21/16 → 2/23/16 |
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Keywords
- Alzheimer disease
- Hippocampus
- Image processing methods
- Magnetic resonance imaging
- Mild cognitive impairment
ASJC Scopus subject areas
- Biomedical Engineering
- Electrical and Electronic Engineering
Cite this
Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment. / Retico, Alessandra; Donatelli, Graziella; Costagli, Mauro; Biagi, Laura; Fantacci, Maria Evelina; Frosini, Daniela; Tognoni, Gloria; Cosottini, Mirco; Tosetti, Michela.
BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016. SciTePress, 2016. p. 124-128.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Semiautomatic image processing tool to measure small structures in magnetic resonance images of the brain at 7 Tesla application to hippocampus subfields of patients with mild cognitive impairment
AU - Retico, Alessandra
AU - Donatelli, Graziella
AU - Costagli, Mauro
AU - Biagi, Laura
AU - Fantacci, Maria Evelina
AU - Frosini, Daniela
AU - Tognoni, Gloria
AU - Cosottini, Mirco
AU - Tosetti, Michela
PY - 2016
Y1 - 2016
N2 - The current availability of Magnetic Resonance (MR) systems that operate at ultra high magnetic field (≥ 7 Tesla) allows the representation of anatomical structures at sub-millimeter resolution. Interestingly, small structures of the brain, such as the subfields of the hippocampus, the inner structures of the basal ganglia and of the brainstem become visible. Suitable software packages that allow analyzing and measuring such small structures are not currently readily available. We developed a semi-automated procedure to measure the thickness of the stratum radiatum and lacunosum-moleculare (SRLM) of the hippocampus. The change in the thickness of this subfield of the hippocampal formation is supposed to have a role in the pathological cognitive decline. Once we developed and validated the semiautomatic procedure on the 7T high-resolution T2∗-weighted images of a healthy volunteer, we carried out a preliminary study on a population affected by Mild Cognitive Impairment to investigate the correlations of the SRLM thickness with the clinical scores of the patients, e.g. the Mini-Mental State Examination score and the Free and Cued Selective Reminding Test.
AB - The current availability of Magnetic Resonance (MR) systems that operate at ultra high magnetic field (≥ 7 Tesla) allows the representation of anatomical structures at sub-millimeter resolution. Interestingly, small structures of the brain, such as the subfields of the hippocampus, the inner structures of the basal ganglia and of the brainstem become visible. Suitable software packages that allow analyzing and measuring such small structures are not currently readily available. We developed a semi-automated procedure to measure the thickness of the stratum radiatum and lacunosum-moleculare (SRLM) of the hippocampus. The change in the thickness of this subfield of the hippocampal formation is supposed to have a role in the pathological cognitive decline. Once we developed and validated the semiautomatic procedure on the 7T high-resolution T2∗-weighted images of a healthy volunteer, we carried out a preliminary study on a population affected by Mild Cognitive Impairment to investigate the correlations of the SRLM thickness with the clinical scores of the patients, e.g. the Mini-Mental State Examination score and the Free and Cued Selective Reminding Test.
KW - Alzheimer disease
KW - Hippocampus
KW - Image processing methods
KW - Magnetic resonance imaging
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=84969776726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969776726&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84969776726
SN - 9789897581700
SP - 124
EP - 128
BT - BIOIMAGING 2016 - 3rd International Conference on Bioimaging, Proceedings; Part of 9th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2016
PB - SciTePress
ER -