Seminal vesicle protein IV and its derived active peptides: A possible physiological role in seminal clotting

Salvatore Metafora, Carla Esposito, Ivana Caputo, Marilena Lepretti, Diana Cassese, Alessandra Dicitore, Pasquale Ferranti, Paola Stiuso

Research output: Contribution to journalArticle

Abstract

Seminal vesicle protein 4 (SV-IV) is a highly flexible molecule that in aqueous solution behaves as a concentration-dependent self-associating system in which the degree of association (monomer ↔ dimer ↔ trimer equilibrium) seems to be related to its biological activities. This review reports the functional role of SV-IV in seminal clotting exerted through the modulation of inflammation, hemostasis, and sperm protection against the damage induced by immunological or reactive oxygen species during the long journey of spermatozoa in the female genital tract.

Original languageEnglish
Pages (from-to)53-59
Number of pages7
JournalSeminars in Thrombosis and Hemostasis
Volume33
Issue number1
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Hemostatic factors
  • Prostate transglutaminase
  • Seminal clotting
  • SV-IV protein

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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