Senescent stroma promotes prostate cancer progression: The role of miR-210

Maria Letizia Taddei, Lorenzo Cavallini, Giuseppina Comito, Elisa Giannoni, Marco Folini, Alberto Marini, Paolo Gandellini, Andrea Morandi, Gianfranco Pintus, Maria Rosaria Raspollini, Nadia Zaffaroni, Paola Chiarugi

Research output: Contribution to journalArticlepeer-review


We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.

Original languageEnglish
Pages (from-to)1729-1746
Number of pages18
JournalMolecular Oncology
Issue number8
Publication statusPublished - Dec 1 2014


  • MiR-210
  • Prostate cancer
  • Senescence
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Medicine


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