TY - JOUR
T1 - Senescent stroma promotes prostate cancer progression
T2 - The role of miR-210
AU - Taddei, Maria Letizia
AU - Cavallini, Lorenzo
AU - Comito, Giuseppina
AU - Giannoni, Elisa
AU - Folini, Marco
AU - Marini, Alberto
AU - Gandellini, Paolo
AU - Morandi, Andrea
AU - Pintus, Gianfranco
AU - Raspollini, Maria Rosaria
AU - Zaffaroni, Nadia
AU - Chiarugi, Paola
PY - 2014/12/1
Y1 - 2014/12/1
N2 - We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.
AB - We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone marrow-derived endothelial precursor cells, facilitating their vasculogenic ability and iii) capillary morphogenesis, proliferation and invasion of human mature endothelial cells. In addition, we highlight that overexpression of the hypoxia-induced miR-210 in young fibroblasts increases their senescence-associated features and converts them into cancer associated fibroblast (CAF)-like cells, able to promote cancer cells EMT, to support angiogenesis and to recruit endothelial precursor cells and monocytes/macrophages.
KW - MiR-210
KW - Prostate cancer
KW - Senescence
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=84911977766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911977766&partnerID=8YFLogxK
U2 - 10.1016/j.molonc.2014.07.009
DO - 10.1016/j.molonc.2014.07.009
M3 - Article
AN - SCOPUS:84911977766
VL - 8
SP - 1729
EP - 1746
JO - Molecular Oncology
JF - Molecular Oncology
SN - 1574-7891
IS - 8
ER -