Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer

R Di Micco

doi:10.1016/j.molmed.2017.10.009

Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer

R Di Micco

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer. © 2017 Elsevier Ltd

Original language	English
Pages (from-to)	1067-1070
Number of pages	4
Journal	Trends in Molecular Medicine
Volume	23
Issue number	12
DOIs	https://doi.org/10.1016/j.molmed.2017.10.009
Publication status	Published - 2017

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title = "Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer",

abstract = "Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer. {\textcopyright} 2017 Elsevier Ltd",

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AB - Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer. © 2017 Elsevier Ltd

U2 - 10.1016/j.molmed.2017.10.009

DO - 10.1016/j.molmed.2017.10.009

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JF - Trends in Molecular Medicine

SN - 1471-4914

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ER -