Abstract
Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer. © 2017 Elsevier Ltd
| Original language | English |
|---|---|
| Pages (from-to) | 1067-1070 |
| Number of pages | 4 |
| Journal | Trends in Molecular Medicine |
| Volume | 23 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2017 |