Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer

R Di Micco

Research output: Contribution to journalArticlepeer-review


Cellular senescence constitutes a stable growth arrest characterized by DNA damage response (DDR) activation and by the senescence-associated secretory phenotype (SASP). SASP, through its paracrine effects, stimulates the immune system for senescence eradication. Similarly, chemotherapy-treated cancers activate an interferon-mediated response to induce anti-tumor immunity. Recent studies now uncover a new role for the innate DNA sensing pathway in the recognition of cytosolic chromatin in senescence and cancer. © 2017 Elsevier Ltd
Original languageEnglish
Pages (from-to)1067-1070
Number of pages4
JournalTrends in Molecular Medicine
Issue number12
Publication statusPublished - 2017


Dive into the research topics of 'Sensing the Breaks: Cytosolic Chromatin in Senescence and Cancer'. Together they form a unique fingerprint.

Cite this