Sensitivity and Detection Rate of a 12-Core Trans-Perineal Prostate Biopsy: Preliminary Report

Bernardo Rocco, Ottavio de Cobelli, Maria Elena Leon, Mario Ferruti, Mauro G. Mastropasqua, Deliu Victor Matei, Giacomo Gazzano, Fabrizio Verweij, Epifanio Scardino, Gennaro Musi, Bob Djavan, Francesco Rocco

Research output: Contribution to journalArticlepeer-review


Objectives: The various prostate biopsy methods are usually compared in terms of the diagnosis rate of prostate cancer. However, the prevalence of cancer in patients with a negative prostatic biopsy is not usually known. We determined the sensitivity and detection rate of 12-core transperineal biopsies in patients not previously investigated for prostate cancer. Methods: We performed prostate biopsy in 63 patients (median age 67 years) before radical cystoprostatectomy for high-grade bladder cancer. We then assessed the relationships between biopsy result, prostate cancer in the surgical specimen, and other variables. Results: 17.2% of patients had a positive biopsy and 54% had prostate cancer on definitive histology. Biopsy sensitivity was 32.3% overall, 75% for clinically significant cancers, and 11% for non-significant cancers. Median PSA was 1.2 ng/ml, PSA levels did not correlate with the presence of prostate cancer, the presence of clinically significant cancer, bioptic diagnosis, or prostate volume. Age correlated with risk of cancer. Conclusions: According to autopsy series, the prevalence of prostate cancer is greater than 50% in males older than 60, yet low PSA levels do not reliably indicate disease absence. The sensitivity of double sextant biopsy is unsatisfactory overall (32%), but acceptable (75%) for diagnosing clinically significant cancer.

Original languageEnglish
Pages (from-to)827-833
Number of pages7
JournalEuropean Urology
Issue number5
Publication statusPublished - May 2006


  • Clinical significance
  • Needle biopsy
  • Prostate cancer
  • PSA
  • Sensitivity

ASJC Scopus subject areas

  • Urology


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