Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy

Giuseppe Liberatore, Claudia Giannotta, Blesson Punnen Sajeev, Emanuela Morenghi, Fabrizia Terenghi, Francesca Gallia, Pietro Emiliano Doneddu, Fiore Manganelli, Dario Cocito, Massimiliano Filosto, Giovanni Antonini, Giuseppe Cosentino, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Eduardo Nobile-Orazio

Research output: Contribution to journalArticlepeer-review


For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.

Original languageEnglish
Article number577288
JournalJournal of Neuroimmunology
Publication statusPublished - Aug 15 2020


  • Anti-MAG polyneuropathy, chronic inflammatory demyelinating polyradiculoneuropathy
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Sensitivity and specificity of a commercial ELISA test for anti-MAG antibodies in patients with neuropathy'. Together they form a unique fingerprint.

Cite this