Abstract
Objective: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first- degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. Results: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. Conclusions: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 623-625 |
| Number of pages | 3 |
| Journal | American Journal of Psychiatry |
| Volume | 152 |
| Issue number | 4 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
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Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder. / Perna, G.; Cocchi, S.; Bertani, A.; Arancio, C.; Bellodi, L.
In: American Journal of Psychiatry, Vol. 152, No. 4, 1995, p. 623-625.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder
AU - Perna, G.
AU - Cocchi, S.
AU - Bertani, A.
AU - Arancio, C.
AU - Bellodi, L.
PY - 1995
Y1 - 1995
N2 - Objective: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first- degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. Results: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. Conclusions: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
AB - Objective: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first- degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. Results: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. Conclusions: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.
UR - http://www.scopus.com/inward/record.url?scp=0028988339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028988339&partnerID=8YFLogxK
M3 - Article
C2 - 7694916
AN - SCOPUS:0028988339
VL - 152
SP - 623
EP - 625
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 4
ER -