Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder

G. Perna, S. Cocchi, A. Bertani, C. Arancio, L. Bellodi

Research output: Contribution to journalArticle

Abstract

Objective: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first- degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. Results: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. Conclusions: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalAmerican Journal of Psychiatry
Volume152
Issue number4
Publication statusPublished - 1995

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Panic Disorder
Healthy Volunteers
Vital Capacity
Inhalation

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Perna, G., Cocchi, S., Bertani, A., Arancio, C., & Bellodi, L. (1995). Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder. American Journal of Psychiatry, 152(4), 623-625.

Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder. / Perna, G.; Cocchi, S.; Bertani, A.; Arancio, C.; Bellodi, L.

In: American Journal of Psychiatry, Vol. 152, No. 4, 1995, p. 623-625.

Research output: Contribution to journalArticle

Perna, G, Cocchi, S, Bertani, A, Arancio, C & Bellodi, L 1995, 'Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder', American Journal of Psychiatry, vol. 152, no. 4, pp. 623-625.
Perna, G. ; Cocchi, S. ; Bertani, A. ; Arancio, C. ; Bellodi, L. / Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder. In: American Journal of Psychiatry. 1995 ; Vol. 152, No. 4. pp. 623-625.
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