Sensitivity to 35% CO2 in healthy first-degree relatives of patients with panic disorder

G. Perna, S. Cocchi, A. Bertani, C. Arancio, L. Bellodi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The authors tested the hypothesis that hyperreactivity to CO2 in healthy subjects represents an underlying familial vulnerability to panic disorder. Method: One vital-capacity inhalation of 35% CO2 and 65% O2 was administered to each of 84 patients with panic disorder, 23 healthy first- degree relatives of probands with panic disorder, and 44 healthy subjects with no family history of panic disorder. Results: The first-degree relatives of the probands with panic disorder reacted significantly more than the healthy subjects and significantly less than the probands. Conclusions: These findings suggest an association between family history of panic disorder and hyperreactivity to 35% CO2 in healthy subjects.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalAmerican Journal of Psychiatry
Volume152
Issue number4
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health

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