Sensitivity to curare in patients with upper and lower motor neurone dysfunction

F. Fiacchino, M. Gemma, M. Bricchi, S. Giombini, B. Regi

Research output: Contribution to journalArticlepeer-review


Sensitivity to the action of nondepolarising relaxants was compared in muscles of upper and lower limbs in four syringomyelic patients undergoing elective neurosurgical procedures. It was observed that muscles with signs of lower motor neurone dysfunction are supersensitive to the action of nondepolarising relaxants. Terminal sprouting of motor axons and the occurrence of newly formed neuromuscular junctions may be responsible for a low synaptic efficacy and may explain the high sensitivity to factors that reduce the safety margin of neuromuscular transmission.

Original languageEnglish
Pages (from-to)980-982
Number of pages3
Issue number11
Publication statusPublished - 1991


  • Neuromuscular relaxants
  • Syringomyelia

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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