Sensitization pattern to inhalant and food allergens in symptomatic children at first evaluation Allergology and Immunology

Alessandro Fiocchi, Valentina Pecora, Carl Johan Petersson, Lamia Dahdah, Magnus P. Borres, Maria J. Amengual, Johannes Huss-Marp, Oscar Mazzina, Francesco Di Girolamo

Research output: Contribution to journalArticle

Abstract

Background: Data on specific IgE sensitization prevalence in children with allergy-like symptoms seen in the primary care setting are rare. Early diagnosis of allergic diseases is important to prevent clinical manifestations, exacerbations or expansion of allergic diseases to other organ systems. The present study aims to assess the usefulness of early serological diagnosis in children with common allergic symptoms. Methods: 532 children (5 years of age) to discriminate atopic from non-atopic subjects. A blood sample of atopic subjects was taken for additional 6-26 specific IgE antibody determinations from a predefined panel using the ImmunoCAP® System. Results: 267 children (50.2 %) were positive in the initial test and were classified as atopic. 14 % were mono-sensitized, 37 % were sensitized to 2-3 allergens and 49 % to more than 3 allergens. The average number of symptoms in the atopic group was 3.3 vs 2.8 in the non-atopic group. The prevalence of sensitization to single allergens was highest for grass and ragweed pollen and house-dust mites (19-28 %). Sensitization to tree allergens was highest for olive tree (16.5 %). Cow's milk and egg white were the most sensitizing foods (~15 %). Food allergen sensitization predominated in younger children (OR = 2.8) whereas the inverse occurred with inhalant allergens (OR = 2.5 to 5.6). A significant positive correlation between patient age and the number of sensitizations was found. Conclusions: Specific IgE sensitization in children with allergy-like symptoms is common. Multiple sensitization is predominating. Number of clinical symptoms was higher in the atopic group compared to the non-atopic without a correlation with the number of positive allergens. Age seems to play a crucial role in the development of sensitization with a significant positive correlation between patient age and the number of sensitizations.

Original languageEnglish
Article number96
JournalItalian Journal of Pediatrics
Volume41
Issue number1
DOIs
Publication statusPublished - Dec 8 2015

Fingerprint

Allergy and Immunology
Allergens
Food
Immunoglobulin E
Early Diagnosis
Hypersensitivity
Pyroglyphidae
Egg White
Olea
Poaceae
Primary Health Care
Milk
Antibodies

Keywords

  • Allergy
  • Children
  • IgE
  • Prevalence
  • Primary Care
  • Sensitization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Sensitization pattern to inhalant and food allergens in symptomatic children at first evaluation Allergology and Immunology. / Fiocchi, Alessandro; Pecora, Valentina; Petersson, Carl Johan; Dahdah, Lamia; Borres, Magnus P.; Amengual, Maria J.; Huss-Marp, Johannes; Mazzina, Oscar; Di Girolamo, Francesco.

In: Italian Journal of Pediatrics, Vol. 41, No. 1, 96, 08.12.2015.

Research output: Contribution to journalArticle

Fiocchi, A, Pecora, V, Petersson, CJ, Dahdah, L, Borres, MP, Amengual, MJ, Huss-Marp, J, Mazzina, O & Di Girolamo, F 2015, 'Sensitization pattern to inhalant and food allergens in symptomatic children at first evaluation Allergology and Immunology', Italian Journal of Pediatrics, vol. 41, no. 1, 96. https://doi.org/10.1186/s13052-015-0204-9
Fiocchi, Alessandro ; Pecora, Valentina ; Petersson, Carl Johan ; Dahdah, Lamia ; Borres, Magnus P. ; Amengual, Maria J. ; Huss-Marp, Johannes ; Mazzina, Oscar ; Di Girolamo, Francesco. / Sensitization pattern to inhalant and food allergens in symptomatic children at first evaluation Allergology and Immunology. In: Italian Journal of Pediatrics. 2015 ; Vol. 41, No. 1.
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AU - Dahdah, Lamia

AU - Borres, Magnus P.

AU - Amengual, Maria J.

AU - Huss-Marp, Johannes

AU - Mazzina, Oscar

AU - Di Girolamo, Francesco

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