Sensorimotor cortex reorganization in alzheimer's disease and metal dysfunction: A MEG study

C. Salustri, F. Tecchio, F. Zappasodi, L. Tomasevic, M. Ercolani, F. Moffa, E. Cassetta, P. M. Rossini, R. Squitti

Research output: Contribution to journalArticle

Abstract

Objective. To verify whether systemic biometals dysfunctions affect neurotransmission in living Alzheimer's disease (AD) patients. Methods. We performed a case-control study using magnetoencephalography to detect sensorimotor fields of AD patients, at rest and during median nerve stimulation. We analyzed position and amount of neurons synchronously activated by the stimulation in both hemispheres to investigate the capability of the primary somatosensory cortex to reorganize its circuitry disrupted by the disease. We also assessed systemic levels of copper, ceruloplasmin, non-Cp copper (i.e., copper not bound to ceruloplasmin), peroxides, transferrin, and total antioxidant capacity. Results. Patients' sensorimotor generators appeared spatially shifted, despite no change of latency and strength, while spontaneous activity sources appeared unchanged. Neuronal reorganization was greater in moderately ill patients, while delta activity increased in severe patients. Non-Cp copper was the only biological variable appearing to be associated with patient sensorimotor transmission. Conclusions. Our data strengthen the notion that non-Cp copper, not copper in general, affects neuronal activity in AD. Significance. High plasticity in the disease early stages in regions controlling more commonly used body parts strengthens the notion that physical and cognitive activities are protective factors against progression of dementia.

Original languageEnglish
Article number638312
JournalInternational Journal of Alzheimer's Disease
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Copper
Alzheimer Disease
Metals
Ceruloplasmin
Magnetoencephalography
Somatosensory Cortex
Median Nerve
Peroxides
Trace Elements
Transferrin
Human Body
Synaptic Transmission
Dementia
Sensorimotor Cortex
Case-Control Studies
Antioxidants
Exercise
Neurons

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Ageing
  • Cellular and Molecular Neuroscience
  • Neurology

Cite this

Salustri, C., Tecchio, F., Zappasodi, F., Tomasevic, L., Ercolani, M., Moffa, F., ... Squitti, R. (2013). Sensorimotor cortex reorganization in alzheimer's disease and metal dysfunction: A MEG study. International Journal of Alzheimer's Disease, 2013, [638312]. https://doi.org/10.1155/2013/638312

Sensorimotor cortex reorganization in alzheimer's disease and metal dysfunction : A MEG study. / Salustri, C.; Tecchio, F.; Zappasodi, F.; Tomasevic, L.; Ercolani, M.; Moffa, F.; Cassetta, E.; Rossini, P. M.; Squitti, R.

In: International Journal of Alzheimer's Disease, Vol. 2013, 638312, 2013.

Research output: Contribution to journalArticle

Salustri, C, Tecchio, F, Zappasodi, F, Tomasevic, L, Ercolani, M, Moffa, F, Cassetta, E, Rossini, PM & Squitti, R 2013, 'Sensorimotor cortex reorganization in alzheimer's disease and metal dysfunction: A MEG study', International Journal of Alzheimer's Disease, vol. 2013, 638312. https://doi.org/10.1155/2013/638312
Salustri, C. ; Tecchio, F. ; Zappasodi, F. ; Tomasevic, L. ; Ercolani, M. ; Moffa, F. ; Cassetta, E. ; Rossini, P. M. ; Squitti, R. / Sensorimotor cortex reorganization in alzheimer's disease and metal dysfunction : A MEG study. In: International Journal of Alzheimer's Disease. 2013 ; Vol. 2013.
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