Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease

Federica Agosta, Maria Assunta Rocca, Elisabetta Pagani, Martina Absinta, Giuseppe Magnani, Alessandra Marcone, Monica Falautano, Giancarlo Comi, Maria Luisa Gorno-Tempini, Massimo Filippi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

This study aimed at elucidating whether (a) brain areas associated with motor function show a change in functional magnetic resonance imaging (fMRI) signal in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD), (b) such change is linear over the course of the disease, and (c) fMRI changes in aMCI and AD are driven by hippocampal atrophy, or, conversely, reflect a nonspecific neuronal network rewiring generically associated to brain tissue damage. FMRI during the performance of a simple motor task with the dominant right-hand, and structural MRI (i.e., dualecho, 3D T1-weighted, and diffusion tensor [DT] MRI sequences) were acquired from 10 AD patients, 15 aMCI patients, and 11 healthy controls. During the simple-motor task, aMCI patients had decreased recruitment of the left (L) inferior frontal gyrus compared to controls, while they showed increased recruitment of L postcentral gyrus and head of L caudate nucleus, and decreased activation of the cingulum compared with AD patients. Effective connectivity was altered between primary sensorimotor cortices (SMC) in aMCI patients vs. controls, and between L SMC, head of L caudate nucleus, and cingulum in AD vs. aMCI patients. Altered fMRI activations and connections were correlated with the hippocampal atrophy in aMCI and with the overall GM microstructural damage in AD. Motor-associated functional cortical changes in aMCI and AD mirror fMRI changes of the cognitive network, suggesting the occurrence of a widespread brain rewiring with increasing structural damage rather than a specific response of cognitive network.

Original languageEnglish
Pages (from-to)515-525
Number of pages11
JournalHuman Brain Mapping
Volume31
Issue number4
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Alzheimer Disease
Magnetic Resonance Imaging
Caudate Nucleus
Atrophy
Brain
Head
Diffusion Magnetic Resonance Imaging
Somatosensory Cortex
Cognitive Dysfunction
Prefrontal Cortex
Hand

Keywords

  • Alzheimer's disease
  • Functional magnetic resonance imaging
  • Functional reorganization
  • Hippocampus
  • Mild cognitive impairment
  • Sensorimotor cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease. / Agosta, Federica; Rocca, Maria Assunta; Pagani, Elisabetta; Absinta, Martina; Magnani, Giuseppe; Marcone, Alessandra; Falautano, Monica; Comi, Giancarlo; Gorno-Tempini, Maria Luisa; Filippi, Massimo.

In: Human Brain Mapping, Vol. 31, No. 4, 04.2010, p. 515-525.

Research output: Contribution to journalArticle

Agosta, Federica ; Rocca, Maria Assunta ; Pagani, Elisabetta ; Absinta, Martina ; Magnani, Giuseppe ; Marcone, Alessandra ; Falautano, Monica ; Comi, Giancarlo ; Gorno-Tempini, Maria Luisa ; Filippi, Massimo. / Sensorimotor network rewiring in mild cognitive impairment and Alzheimer's disease. In: Human Brain Mapping. 2010 ; Vol. 31, No. 4. pp. 515-525.
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