Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation

Angelo Quartarone, Vincenzo Rizzo, Carmen Terranova, Demetrio Milardi, Daniele Bruschetta, Maria Felice Ghilardi, Paolo Girlanda

Research output: Contribution to journalArticle

Abstract

It has been proposed that synchronous and convergent afferent input arising from repetitive motor tasks may play an important role in driving the maladaptive cortical plasticity seen in focal hand dystonia (FHD).This hypothesis receives support from several sources. First, it has been reported that in subjects with FHD, paired associative stimulation produces an abnormal increase in corticospinal excitability, which was not confined to stimulated mus- cles.These findings provide support for the role of excessive plasticity in FHD. Second, the genetic contribution to the dystonias is increasingly recognized indicating that repetitive, stereotyped afferent inputs may lead to late-onset dystonia, such as FHD, more rapidly in genetically susceptible individuals. It can be postulated, according to the two factor hypothesis that dystonia is triggered and maintained by the concurrence of environmental factors such as repetitive training and subtle abnormal mechanisms of plasticity within somatosensory loop. In the present review, we examine the contribution of sensory-motor integration in the pathophysiology of primary dystonia. In addition, we will discuss the role of non-invasive brain stimulation as therapeutic approach in FHD.

Original languageEnglish
Article number956
JournalFrontiers in Human Neuroscience
Volume8
Issue numberDEC
DOIs
Publication statusPublished - Dec 5 2014

Fingerprint

Dystonia
Brain
Dystonic Disorders
Focal Task-Specific Dystonia
Muscles
Therapeutics

Keywords

  • Cortical plasticity
  • Focal dystonia
  • LTP
  • Rehabilitation
  • Sensory-motor integration
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neurology
  • Biological Psychiatry
  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Quartarone, A., Rizzo, V., Terranova, C., Milardi, D., Bruschetta, D., Ghilardi, M. F., & Girlanda, P. (2014). Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation. Frontiers in Human Neuroscience, 8(DEC), [956]. https://doi.org/10.3389/fnhum.2014.00956

Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation. / Quartarone, Angelo; Rizzo, Vincenzo; Terranova, Carmen; Milardi, Demetrio; Bruschetta, Daniele; Ghilardi, Maria Felice; Girlanda, Paolo.

In: Frontiers in Human Neuroscience, Vol. 8, No. DEC, 956, 05.12.2014.

Research output: Contribution to journalArticle

Quartarone, A, Rizzo, V, Terranova, C, Milardi, D, Bruschetta, D, Ghilardi, MF & Girlanda, P 2014, 'Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation', Frontiers in Human Neuroscience, vol. 8, no. DEC, 956. https://doi.org/10.3389/fnhum.2014.00956
Quartarone, Angelo ; Rizzo, Vincenzo ; Terranova, Carmen ; Milardi, Demetrio ; Bruschetta, Daniele ; Ghilardi, Maria Felice ; Girlanda, Paolo. / Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation. In: Frontiers in Human Neuroscience. 2014 ; Vol. 8, No. DEC.
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