Sensory neuron diseases

Angelo Sghirlanzoni, Davide Pareyson, Giuseppe Lauria

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Sensory neuron diseases (SND) are a distinct subgroup of peripheral-nervous-system diseases, first acknowledged in 1948. Acquired SND have a subacute or chronic course and are associated with systemic immune-mediated diseases, vitamin intoxication or deficiency, neurotoxic drugs, and life-threatening diseases such as cancer. SND are commonly idiopathic but can be genetic diseases; the latter tend to involve subtypes of sensory neurons and are associated with certain clinical pictures. The loss of sensory neurons in dorsal root ganglia causes the degeneration of short and long peripheral axons and central sensory projections in the posterior columns. This pathological process leads to a pattern of sensory nerve degeneration that is not length dependent and explains distinct clinical and neurophysiological abnormalities. Here we propose a comprehensive approach to the diagnosis of acquired and hereditary SND and discuss clinical, genetic, neurophysiological, neuroradiological, and neuropathological assessments.

Original languageEnglish
Pages (from-to)349-361
Number of pages13
JournalThe Lancet Neurology
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 1 2005

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Sensory Receptor Cells
Nerve Degeneration
Inborn Genetic Diseases
Immune System Diseases
Spinal Ganglia
Peripheral Nervous System Diseases
Pathologic Processes
Vitamins
Axons
Pharmaceutical Preparations
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Sensory neuron diseases. / Sghirlanzoni, Angelo; Pareyson, Davide; Lauria, Giuseppe.

In: The Lancet Neurology, Vol. 4, No. 6, 01.06.2005, p. 349-361.

Research output: Contribution to journalArticle

Sghirlanzoni, Angelo ; Pareyson, Davide ; Lauria, Giuseppe. / Sensory neuron diseases. In: The Lancet Neurology. 2005 ; Vol. 4, No. 6. pp. 349-361.
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