Sensory representation of passive movement kinematics by rat's spinocerebellar Purkinje cells

Genoveffa Giaquinta, Maria Stella Valle, Cinzia Caserta, Antonino Casabona, Gianfranco Bosco, Vincenzo Perciavalle

Research output: Contribution to journalArticle

Abstract

In this paper we examined Purkinje cells' sensory representations of kinematic parameters of passive movements imposed to the forelimb of anesthetized rats. Simple spike Purkinje cell activity was recorded while the rat's ipsilateral forearm was moved passively along circular footpaths at two different speeds. We found that the activity of 35.33% (165/467) of the neurons was significantly modulated during movement cycles. A multivariate regression analysis indicated that movement direction was the predominant factor in determining Purkinje cell activity, whereas movement velocity (i.e. the combination of movement direction and speed) was represented to a much lesser degree. Based on this result, we might suggest that a cortical efferent copy is necessary to the cerebellum in order to elaborate a movement velocity signal. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume285
Issue number1
DOIs
Publication statusPublished - May 5 2000

Keywords

  • Electrophysiology
  • Forelimb passive movement
  • Paleocerebellum
  • Purkinje cells
  • Rat
  • Simple spike activity

ASJC Scopus subject areas

  • Neuroscience(all)

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    Giaquinta, G., Valle, M. S., Caserta, C., Casabona, A., Bosco, G., & Perciavalle, V. (2000). Sensory representation of passive movement kinematics by rat's spinocerebellar Purkinje cells. Neuroscience Letters, 285(1), 41-44. https://doi.org/10.1016/S0304-3940(00)01020-X