Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study

Stefano Amadio, Elise Houdayer, Francesca Bianchi, Habtom Tesfaghebriel Tekle, Ivan Pietro Urban, Calogera Butera, Roberta Guerriero, Marco Cursi, Letizia Leocani, Giancarlo Comi, Ubaldo Del Carro

Research output: Contribution to journalArticle

Abstract

Background: Sensory tricks such as touching the face with fingertips often improve cervical dystonia [CD]. This study is to determine whether sensory tricks modulate motor cortex excitability, assessed by paired-pulse transcranial magnetic stimulation [p-pTMS]. Methods: Eight patients with rotational CD underwent p-pTMS, at rest and when the sensory trick was applied. To test intracortical inhibition [ICI] and facilitation [ICF], the amplitude ratio between conditioned and unconditioned cortical motor evoked potentials was measured at several interstimulus intervals (ISI 1, 3, 15, and 20 ms) and compared with controls mimicking patients' sensory tricks. Results: At rest, a significant ICF enhancement was found at ISIs 15 through 20 in patients compared with controls, whereas no significant ICI changes were observed. Sensory tricks significantly reduced the abnormal ICF in patients and did not induce any change in controls. Conclusions: In our CD patients, sensory tricks seem to improve dystonia through an inhibitory effect on motor cortex excitability.

Original languageEnglish
Pages (from-to)1185-1188
Number of pages4
JournalMovement Disorders
Volume29
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Cervical dystonia
  • Intracortical facilitation
  • Intracortical inhibition
  • Sensory trick
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study'. Together they form a unique fingerprint.

  • Cite this

    Amadio, S., Houdayer, E., Bianchi, F., Tesfaghebriel Tekle, H., Urban, I. P., Butera, C., Guerriero, R., Cursi, M., Leocani, L., Comi, G., & Del Carro, U. (2014). Sensory tricks and brain excitability in cervical dystonia: A transcranial magnetic stimulation study. Movement Disorders, 29(9), 1185-1188. https://doi.org/10.1002/mds.25888