La cefalea sintomo "sentinella" nel personale addetto alla preparazione e somministrazione di chemioterapici antiblastici

Translated title of the contribution: Sentinel headache symptom in personnel assigned to the preparation and administration of antiblastic chemotherapy drugs

Ennio Pucci, F. Matozzo, P. Luppi, G. Micoli, C. Sottani, C. Minoia, G. Sandrini, G. Nappi

Research output: Contribution to journalArticlepeer-review

Abstract

The increased prevalence of neoplastic diseases observed over the last years has resulted for in more frequent operations of preparation and administration of antiblastic drugs performed by the medical personnel. In this study, we examined a group of subjects involved in the preparation of ACNU, Methotrexate, Novantrone, Vincristine, Cyclophosphamide, Carboplatinum, Mythoxantrone, in order to elucidate whether headache may represent an early symptom of exposure to these products. At the same time, we measured the degree of pollution in the air surrounding the vertical laminar flow aspiration cabinet used for drug preparation. The 66.6% of the 12 subjects studied, 9 females and 3 males, complained of headache. However, the environmental detection using high performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC/MS/MS) gave negative results with respect to a possible environmental damage. These findings suggest that headache is the onset symptom of the toxic effect of antiblastic chemiotherapics in the medical personnel involved in drug preparation and administration.

Translated title of the contributionSentinel headache symptom in personnel assigned to the preparation and administration of antiblastic chemotherapy drugs
Original languageItalian
Pages (from-to)412-416
Number of pages5
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume27
Issue number4
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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