Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy

Simona De Grazia, Gianvito Lanave, Giovanni Maurizio Giammanco, Maria Cristina Medici, Flora De Conto, Fabio Tummolo, Adriana Calderaro, Floriana Bonura, Noemi Urone, Anna Morea, Daniela Loconsole, Cristiana Catella, Mariarosaria Marinaro, Antonio Parisi, Vito Martella, Maria Chironna

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Noroviruses are one of the leading causes of gastro-enteric diseases worldwide in all age groups. Novel epidemic noroviruses with GII.P16 polymerase and GII.2 or GII.4 capsid type have emerged worldwide in late 2015 and in 2016. We performed a molecular epidemiological study of the noroviruses circulating in Italy to investigate the emergence of new norovirus strains. Sentinel hospital-based surveillance, in three different Italian regions, revealed increased prevalence of norovirus infection in children (<15 years) in 2016 (14.4% versus 9.8% in 2015) and the emergence of GII.P16 strains in late 2016, which accounted for 23.0% of norovirus infections. The majority of the strains with a GII.P16 polymerase showed a GII.2 capsid genotype (79.5%). Also, a marked circulation of strains with a GII.17 capsid (14.0%) was observed, chiefly in early 2016. The emergence and global spread of non-GII.4 noroviruses pose challenges for the development of vaccine strategies.

Original languageEnglish
Article numbere0208184
JournalPLoS One
Volume13
Issue number12
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

Fingerprint

Norovirus
gastroenteritis
Gastroenteritis
Italy
monitoring
Infection
capsid
Capsid
infection
Vaccines
vaccine development
cyhalothrin
digestive system diseases
epidemiological studies
Epidemiologic Studies
Age Groups
Genotype
genotype

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

De Grazia, S., Lanave, G., Giammanco, G. M., Medici, M. C., De Conto, F., Tummolo, F., ... Chironna, M. (2018). Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy. PLoS One, 13(12), [e0208184]. https://doi.org/10.1371/journal.pone.0208184

Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy. / De Grazia, Simona; Lanave, Gianvito; Giammanco, Giovanni Maurizio; Medici, Maria Cristina; De Conto, Flora; Tummolo, Fabio; Calderaro, Adriana; Bonura, Floriana; Urone, Noemi; Morea, Anna; Loconsole, Daniela; Catella, Cristiana; Marinaro, Mariarosaria; Parisi, Antonio; Martella, Vito; Chironna, Maria.

In: PLoS One, Vol. 13, No. 12, e0208184, 01.12.2018.

Research output: Contribution to journalArticle

De Grazia, S, Lanave, G, Giammanco, GM, Medici, MC, De Conto, F, Tummolo, F, Calderaro, A, Bonura, F, Urone, N, Morea, A, Loconsole, D, Catella, C, Marinaro, M, Parisi, A, Martella, V & Chironna, M 2018, 'Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy', PLoS One, vol. 13, no. 12, e0208184. https://doi.org/10.1371/journal.pone.0208184
De Grazia, Simona ; Lanave, Gianvito ; Giammanco, Giovanni Maurizio ; Medici, Maria Cristina ; De Conto, Flora ; Tummolo, Fabio ; Calderaro, Adriana ; Bonura, Floriana ; Urone, Noemi ; Morea, Anna ; Loconsole, Daniela ; Catella, Cristiana ; Marinaro, Mariarosaria ; Parisi, Antonio ; Martella, Vito ; Chironna, Maria. / Sentinel hospital-based surveillance for norovirus infection in children with gastroenteritis between 2015 and 2016 in Italy. In: PLoS One. 2018 ; Vol. 13, No. 12.
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