TY - JOUR
T1 - Sentinel lymph node biopsy in patients with malignant melanoma
T2 - analysis of post-operative complications
AU - Solari, Nicola
AU - Bertoglio, Sergio
AU - Boscaneanu, Alexandru
AU - Minuto, Michele
AU - Reina, Simona
AU - Palombo, Denise
AU - Bruzzi, Paolo
AU - Cafiero, Ferdinando
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background: This study investigates the incidence of post-operative complications and risk factors of sentinel lymph node biopsy (SLNB) in melanoma patients. Methods: A retrospective cohort study was conducted at a single cancer institution on 408 consecutive SLNBs. Results: Fifty-five post-operative complications occurred in 39 (9.5%) patients and included: wound infection in 24 (5.9%), seroma and lymphorrhea in 15 (3.7%), wound dehiscence in seven (1.7%), lymphocele in six (1.5%) and others in three (0.7%). Univariate analysis failed to identify possible risk factors (i.e. gender, age, lymph node region, number of excised lymph nodes, Breslow index, pT levels, comorbidities, length of surgery and hospital stay). Metastatic sentinel nodes occurred in four of 135 (3%) patients with thin melanoma (Breslow <1 mm) and in 68 of 262 (25.9%) patients with Breslow >1 mm. Conclusion: For patients with thin melanoma in whom the incidence of lymph node metastasis is low, the reported post-operative morbidity of almost 10% of SLNB highlights the need for careful patient selection.
AB - Background: This study investigates the incidence of post-operative complications and risk factors of sentinel lymph node biopsy (SLNB) in melanoma patients. Methods: A retrospective cohort study was conducted at a single cancer institution on 408 consecutive SLNBs. Results: Fifty-five post-operative complications occurred in 39 (9.5%) patients and included: wound infection in 24 (5.9%), seroma and lymphorrhea in 15 (3.7%), wound dehiscence in seven (1.7%), lymphocele in six (1.5%) and others in three (0.7%). Univariate analysis failed to identify possible risk factors (i.e. gender, age, lymph node region, number of excised lymph nodes, Breslow index, pT levels, comorbidities, length of surgery and hospital stay). Metastatic sentinel nodes occurred in four of 135 (3%) patients with thin melanoma (Breslow <1 mm) and in 68 of 262 (25.9%) patients with Breslow >1 mm. Conclusion: For patients with thin melanoma in whom the incidence of lymph node metastasis is low, the reported post-operative morbidity of almost 10% of SLNB highlights the need for careful patient selection.
KW - melanoma
KW - post-operative complication
KW - risk factor
KW - sentinel lymph node biopsy
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U2 - 10.1111/ans.15358
DO - 10.1111/ans.15358
M3 - Article
C2 - 31368164
AN - SCOPUS:85070072147
VL - 89
SP - 1041
EP - 1044
JO - ANZ Journal of Surgery
JF - ANZ Journal of Surgery
SN - 1445-1433
IS - 9
ER -