Sentinel lymph node mapping and biopsy for breast cancer: A review of the literature relative to 4791 procedures

Sergio Sandrucci, Paola Sorba Casalegno, Pierluigi Percivale, Marinella Mistrangelo, Emilio Bombardieri, Sergio Bertoglio

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The status of axillary nodes is the most important prognostic factor in breast cancer to select patient subgroups for adjuvant chemotherapy; the current standard of care for surgical management of invasive breast cancer is complete removal of the tumor by either mastectomy or lumpectomy followed by axillary lymph node dissection (ALND). The recent introduction of intraoperative lymphatic mapping and sentinel lymph node biopsy (SLND) represents a major new opportunity for appropriate and less invasive surgical management of many tumors. There is an almost uniformly enthusiasm concerning the potential of this technique in breast carcinoma management, shown by published data. A peculiar attention to the so-called 'sentinel node debate' in breast cancer surgery is a constant in the last years issues of the major medical journals. Even patients have become more aware about medical enthusiasm and their request of concise information on the topic and the possibilities of this approach is an increasing reality in medical practice. The aim of this paper is to review recent literature to offer an overview about the main controversial methodological aspects and a wide analysis of reported results. The most significative international literature papers from Medline were retrieved from 1993 to September 1999, and 4782 procedures were analysed. This extensive review of the literature has confirmed accuracy, feasibility and reliability of the SN detecting technique in axillary mapping. Provided a good proficiency in SN localisation and pathological evaluation, human resources and efforts should be mainly focused on its clinical validation as an alternative to ALND instead of on further phase I- II clinical studies.

Original languageEnglish
Pages (from-to)425-434
Number of pages10
JournalTumori
Volume85
Issue number6
Publication statusPublished - Nov 1 1999

Fingerprint

Sentinel Lymph Node Biopsy
Breast Neoplasms
Lymph Node Excision
Segmental Mastectomy
Mastectomy
Adjuvant Chemotherapy
Standard of Care
Neoplasms

Keywords

  • Breast neoplasms
  • Lymphatic mapping
  • Metastases
  • Sentinel lymph node

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sandrucci, S., Casalegno, P. S., Percivale, P., Mistrangelo, M., Bombardieri, E., & Bertoglio, S. (1999). Sentinel lymph node mapping and biopsy for breast cancer: A review of the literature relative to 4791 procedures. Tumori, 85(6), 425-434.

Sentinel lymph node mapping and biopsy for breast cancer : A review of the literature relative to 4791 procedures. / Sandrucci, Sergio; Casalegno, Paola Sorba; Percivale, Pierluigi; Mistrangelo, Marinella; Bombardieri, Emilio; Bertoglio, Sergio.

In: Tumori, Vol. 85, No. 6, 01.11.1999, p. 425-434.

Research output: Contribution to journalArticle

Sandrucci, S, Casalegno, PS, Percivale, P, Mistrangelo, M, Bombardieri, E & Bertoglio, S 1999, 'Sentinel lymph node mapping and biopsy for breast cancer: A review of the literature relative to 4791 procedures', Tumori, vol. 85, no. 6, pp. 425-434.
Sandrucci S, Casalegno PS, Percivale P, Mistrangelo M, Bombardieri E, Bertoglio S. Sentinel lymph node mapping and biopsy for breast cancer: A review of the literature relative to 4791 procedures. Tumori. 1999 Nov 1;85(6):425-434.
Sandrucci, Sergio ; Casalegno, Paola Sorba ; Percivale, Pierluigi ; Mistrangelo, Marinella ; Bombardieri, Emilio ; Bertoglio, Sergio. / Sentinel lymph node mapping and biopsy for breast cancer : A review of the literature relative to 4791 procedures. In: Tumori. 1999 ; Vol. 85, No. 6. pp. 425-434.
@article{4965557e2adc41119050a52633d58165,
title = "Sentinel lymph node mapping and biopsy for breast cancer: A review of the literature relative to 4791 procedures",
abstract = "The status of axillary nodes is the most important prognostic factor in breast cancer to select patient subgroups for adjuvant chemotherapy; the current standard of care for surgical management of invasive breast cancer is complete removal of the tumor by either mastectomy or lumpectomy followed by axillary lymph node dissection (ALND). The recent introduction of intraoperative lymphatic mapping and sentinel lymph node biopsy (SLND) represents a major new opportunity for appropriate and less invasive surgical management of many tumors. There is an almost uniformly enthusiasm concerning the potential of this technique in breast carcinoma management, shown by published data. A peculiar attention to the so-called 'sentinel node debate' in breast cancer surgery is a constant in the last years issues of the major medical journals. Even patients have become more aware about medical enthusiasm and their request of concise information on the topic and the possibilities of this approach is an increasing reality in medical practice. The aim of this paper is to review recent literature to offer an overview about the main controversial methodological aspects and a wide analysis of reported results. The most significative international literature papers from Medline were retrieved from 1993 to September 1999, and 4782 procedures were analysed. This extensive review of the literature has confirmed accuracy, feasibility and reliability of the SN detecting technique in axillary mapping. Provided a good proficiency in SN localisation and pathological evaluation, human resources and efforts should be mainly focused on its clinical validation as an alternative to ALND instead of on further phase I- II clinical studies.",
keywords = "Breast neoplasms, Lymphatic mapping, Metastases, Sentinel lymph node",
author = "Sergio Sandrucci and Casalegno, {Paola Sorba} and Pierluigi Percivale and Marinella Mistrangelo and Emilio Bombardieri and Sergio Bertoglio",
year = "1999",
month = "11",
day = "1",
language = "English",
volume = "85",
pages = "425--434",
journal = "Tumori",
issn = "0300-8916",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Sentinel lymph node mapping and biopsy for breast cancer

T2 - A review of the literature relative to 4791 procedures

AU - Sandrucci, Sergio

AU - Casalegno, Paola Sorba

AU - Percivale, Pierluigi

AU - Mistrangelo, Marinella

AU - Bombardieri, Emilio

AU - Bertoglio, Sergio

PY - 1999/11/1

Y1 - 1999/11/1

N2 - The status of axillary nodes is the most important prognostic factor in breast cancer to select patient subgroups for adjuvant chemotherapy; the current standard of care for surgical management of invasive breast cancer is complete removal of the tumor by either mastectomy or lumpectomy followed by axillary lymph node dissection (ALND). The recent introduction of intraoperative lymphatic mapping and sentinel lymph node biopsy (SLND) represents a major new opportunity for appropriate and less invasive surgical management of many tumors. There is an almost uniformly enthusiasm concerning the potential of this technique in breast carcinoma management, shown by published data. A peculiar attention to the so-called 'sentinel node debate' in breast cancer surgery is a constant in the last years issues of the major medical journals. Even patients have become more aware about medical enthusiasm and their request of concise information on the topic and the possibilities of this approach is an increasing reality in medical practice. The aim of this paper is to review recent literature to offer an overview about the main controversial methodological aspects and a wide analysis of reported results. The most significative international literature papers from Medline were retrieved from 1993 to September 1999, and 4782 procedures were analysed. This extensive review of the literature has confirmed accuracy, feasibility and reliability of the SN detecting technique in axillary mapping. Provided a good proficiency in SN localisation and pathological evaluation, human resources and efforts should be mainly focused on its clinical validation as an alternative to ALND instead of on further phase I- II clinical studies.

AB - The status of axillary nodes is the most important prognostic factor in breast cancer to select patient subgroups for adjuvant chemotherapy; the current standard of care for surgical management of invasive breast cancer is complete removal of the tumor by either mastectomy or lumpectomy followed by axillary lymph node dissection (ALND). The recent introduction of intraoperative lymphatic mapping and sentinel lymph node biopsy (SLND) represents a major new opportunity for appropriate and less invasive surgical management of many tumors. There is an almost uniformly enthusiasm concerning the potential of this technique in breast carcinoma management, shown by published data. A peculiar attention to the so-called 'sentinel node debate' in breast cancer surgery is a constant in the last years issues of the major medical journals. Even patients have become more aware about medical enthusiasm and their request of concise information on the topic and the possibilities of this approach is an increasing reality in medical practice. The aim of this paper is to review recent literature to offer an overview about the main controversial methodological aspects and a wide analysis of reported results. The most significative international literature papers from Medline were retrieved from 1993 to September 1999, and 4782 procedures were analysed. This extensive review of the literature has confirmed accuracy, feasibility and reliability of the SN detecting technique in axillary mapping. Provided a good proficiency in SN localisation and pathological evaluation, human resources and efforts should be mainly focused on its clinical validation as an alternative to ALND instead of on further phase I- II clinical studies.

KW - Breast neoplasms

KW - Lymphatic mapping

KW - Metastases

KW - Sentinel lymph node

UR - http://www.scopus.com/inward/record.url?scp=0033388547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033388547&partnerID=8YFLogxK

M3 - Article

C2 - 10774561

AN - SCOPUS:0033388547

VL - 85

SP - 425

EP - 434

JO - Tumori

JF - Tumori

SN - 0300-8916

IS - 6

ER -