Sentinel lymph node mapping opens a new perspective in the surgical management of early-stage breast cancer: A combined approach with vital blue dye lymphatic mapping and radioguided surgery

Giuseppe Canavese, Marco Gipponi, Alessandra Catturich, Carmine Di Somma, Carlo Vecchio, Francesco Rosato, Daniela Tomei, Ferdinando Cafiero, Luciano Moresco, Guido Nicolò, Franca Carli, Giuseppe Villa, Ferdinando Buffoni, Fausto Badellino

Research output: Contribution to journalArticle

Abstract

Recent studies have demonstrated the possibility of identifying the sentinel lymph node (sN) as a reliable predictor of axillary lymph node status in both cutaneous melanoma and breast cancer. However, some important issues need further definition: (1) optimization of the technique for intraoperative detection of the sN; (2) predictive value of the sN as regards axillary lymph node status, and (3) reliability of intraoperative histology of the sN. We report our experience in sN mapping in patients with Stage I- II breast cancer, with the aim of assessing: (1) the feasibility of lymphatic mapping with a combined approach (vital blue dye lymphatic mapping and radioguided surgery); (2) the agreement of the intraoperative histologic examination of the sN, by means of hematoxylin and eosin staining with final histology, and (3) the accuracy of sN histology as a predictor of axillary lymph node status.

Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalSeminars in Surgical Oncology
Volume15
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Axilla
  • Biopsy
  • Breast neoplasms
  • False negative reactions
  • Intraoperative period
  • Lymph node excision
  • Lymph nodes/radionuclide imaging/ pathology
  • Lymphatic metastasis
  • Melanoma
  • Neoplasm recurrence
  • Neoplasm staging
  • Predictive value of tests
  • Radioimmunodetection
  • Rosaniline dyes
  • Sensitivity and specificity
  • Staining
  • Technetium compounds

ASJC Scopus subject areas

  • Surgery
  • Oncology

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  • Cite this

    Canavese, G., Gipponi, M., Catturich, A., Di Somma, C., Vecchio, C., Rosato, F., Tomei, D., Cafiero, F., Moresco, L., Nicolò, G., Carli, F., Villa, G., Buffoni, F., & Badellino, F. (1998). Sentinel lymph node mapping opens a new perspective in the surgical management of early-stage breast cancer: A combined approach with vital blue dye lymphatic mapping and radioguided surgery. Seminars in Surgical Oncology, 15(4), 272-277. https://doi.org/10.1002/(SICI)1098-2388(199812)15:4<272::AID-SSU17>3.0.CO;2-I