Sentinel node biopsy in early vulvar cancer

C. De Cicco, M. Sideri, M. Bartolomei, C. Grana, M. Cremonesi, M. Fiorenza, A. Maggioni, L. Bocciolone, C. Mangioni, N. Colombo, G. Paganelli

Research output: Contribution to journalArticle

Abstract

Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1-T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node was positive, the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalBritish Journal of Cancer
Volume82
Issue number2
Publication statusPublished - 2000

Keywords

  • Lymph node
  • Lymphadenectomy
  • Lymphoscintigraphy
  • Sentinel node
  • Vulvar cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    De Cicco, C., Sideri, M., Bartolomei, M., Grana, C., Cremonesi, M., Fiorenza, M., Maggioni, A., Bocciolone, L., Mangioni, C., Colombo, N., & Paganelli, G. (2000). Sentinel node biopsy in early vulvar cancer. British Journal of Cancer, 82(2), 295-299.