Abstract
Aims: Negative sentinel node may predict tumour-free axillary nodes in breast cancer. We report the performance of sentinel node dissection at our Institution. Methods: We analysed data from 212 consecutive women with primary invasive breast tumours less than 3 cm in diameter and no axillary lymphadenopathy who underwent radioguided sentinel node dissection by means of 99mTc-colloidal albumin between 1999 and 2002. Completion axillary node dissection was performed if sentinel nodes contained metastases or if no sentinel nodes were identified. Results: Sentinel nodes were identified in 207/212 of the patients. Fifty-seven patients had tumour-positive sentinel nodes. Only tumour diameter showed significant association with sentinel node status (p <0.000). Per-operative histologic evaluation had a sensitivity of 67.3% and a negative predictive value of 90.4%. No subset of sentinel node positive patients was identified for whom axillary node dissection could be safely avoided. No recurrences were detected at a median follow-up of 15 months. Conclusion: Radioguided sentinel node dissection offers a reliable way to assess nodal status in most breast cancer patients. In our experience, both preoperative lymphoscintigraphy and intraoperative histologic evaluation add useful information to the procedure.
| Original language | English |
|---|---|
| Pages (from-to) | 703-706 |
| Number of pages | 4 |
| Journal | European Journal of Surgical Oncology |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Nov 2003 |
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Keywords
- Breast neoplasms
- Radionuclide imaging
- Sentinel lymph node biopsy
ASJC Scopus subject areas
- Oncology
- Surgery
Cite this
Sentinel node dissection as definitive treatment for node negative breast cancer patients. / Ponzone, Ricardo; Biglia, N.; Maggiorotto, F.; Kubatzki, F.; Elia, O.; De Rosa, G.; Sismondi, P.
In: European Journal of Surgical Oncology, Vol. 29, No. 9, 11.2003, p. 703-706.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sentinel node dissection as definitive treatment for node negative breast cancer patients
AU - Ponzone, Ricardo
AU - Biglia, N.
AU - Maggiorotto, F.
AU - Kubatzki, F.
AU - Elia, O.
AU - De Rosa, G.
AU - Sismondi, P.
PY - 2003/11
Y1 - 2003/11
N2 - Aims: Negative sentinel node may predict tumour-free axillary nodes in breast cancer. We report the performance of sentinel node dissection at our Institution. Methods: We analysed data from 212 consecutive women with primary invasive breast tumours less than 3 cm in diameter and no axillary lymphadenopathy who underwent radioguided sentinel node dissection by means of 99mTc-colloidal albumin between 1999 and 2002. Completion axillary node dissection was performed if sentinel nodes contained metastases or if no sentinel nodes were identified. Results: Sentinel nodes were identified in 207/212 of the patients. Fifty-seven patients had tumour-positive sentinel nodes. Only tumour diameter showed significant association with sentinel node status (p <0.000). Per-operative histologic evaluation had a sensitivity of 67.3% and a negative predictive value of 90.4%. No subset of sentinel node positive patients was identified for whom axillary node dissection could be safely avoided. No recurrences were detected at a median follow-up of 15 months. Conclusion: Radioguided sentinel node dissection offers a reliable way to assess nodal status in most breast cancer patients. In our experience, both preoperative lymphoscintigraphy and intraoperative histologic evaluation add useful information to the procedure.
AB - Aims: Negative sentinel node may predict tumour-free axillary nodes in breast cancer. We report the performance of sentinel node dissection at our Institution. Methods: We analysed data from 212 consecutive women with primary invasive breast tumours less than 3 cm in diameter and no axillary lymphadenopathy who underwent radioguided sentinel node dissection by means of 99mTc-colloidal albumin between 1999 and 2002. Completion axillary node dissection was performed if sentinel nodes contained metastases or if no sentinel nodes were identified. Results: Sentinel nodes were identified in 207/212 of the patients. Fifty-seven patients had tumour-positive sentinel nodes. Only tumour diameter showed significant association with sentinel node status (p <0.000). Per-operative histologic evaluation had a sensitivity of 67.3% and a negative predictive value of 90.4%. No subset of sentinel node positive patients was identified for whom axillary node dissection could be safely avoided. No recurrences were detected at a median follow-up of 15 months. Conclusion: Radioguided sentinel node dissection offers a reliable way to assess nodal status in most breast cancer patients. In our experience, both preoperative lymphoscintigraphy and intraoperative histologic evaluation add useful information to the procedure.
KW - Breast neoplasms
KW - Radionuclide imaging
KW - Sentinel lymph node biopsy
UR - http://www.scopus.com/inward/record.url?scp=0344896729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344896729&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2003.08.005
DO - 10.1016/j.ejso.2003.08.005
M3 - Article
C2 - 14602486
AN - SCOPUS:0344896729
VL - 29
SP - 703
EP - 706
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 9
ER -