Sentinel node mapping with radiotracer alone in vulvar cancer: A five year single-centre experience and literature review

S. Bogliolo, P. Marchiole, P. Sala, E. Giardina, G. Villa, E. Fulcheri, M. Valenzano Menada

Research output: Contribution to journalArticlepeer-review


Purpose of investigation: The pathologic status of lymph node represents the most important prognostic factor in vulvar cancer patients, but a complete groin dissection is associated with high post-operative morbidity. Sentinel lymph node (SLN) could be representative of the totality of regional lymph nodes and consequently its biopsy might have a significant impact on clinical management in vulvar cancer patients. Materials and Methods: From January 2006 to December 2010 45 patients with vulvar carcinoma are evaluated. Preoperative lymphatic mapping with technetium-99m-labeled nanocolloid was performed in all patients, followed by radioguided intraoperative detection. The detection rate is 100% of patients. All the SLNs were dissected separately for histopathological evaluation and a routine inguinofemoral lymphadenectomy was performed. Results: Nine patients had positive SLNs. In the remaining 36 patients with negative SLNs, one of them showed positive non-SLNs at histological examination. It was the only false negative case in the present series. Conclusions: Based on literature review, lymphoscintigraphy and sentinel node biopsy under gamma-detecting probe guidance offer a reliable and careful method to identify sentinel node in early vulvar cancer. Taking certain guidelines, SLN biopsy seems to be a safe alternative to inguinofemoral node dissection in order to reduce morbidity of surgical treatment.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalEuropean Journal of Gynaecological Oncology
Issue number1
Publication statusPublished - 2015


  • Groin dissection
  • Radiotracer
  • Sentinel-node biopsy
  • Squamous cells carcinoma
  • Vulvar cancer

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Medicine(all)


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