Separation of beta adrenoceptor antagonist enantiomers by high resolution capillary gas chromatography

S. Caccia, C. Chiabrando, P. De Ponte, R. Fanelli

Research output: Contribution to journalArticle

Abstract

The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N, O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalJournal of Chromatographic Science
Volume16
Issue number11
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

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