Separation of beta adrenoceptor antagonist enantiomers by high resolution capillary gas chromatography

S. Caccia, C. Chiabrando, P. De Ponte, R. Fanelli

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N, O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.

Original languageEnglish
Pages (from-to)543-546
Number of pages4
JournalJournal of Chromatographic Science
Volume16
Issue number11
DOIs
Publication statusPublished - 1978

Fingerprint

Enantiomers
Gas chromatography
Gas Chromatography
Adrenergic Receptors
Glass
Chlorides
Liquid chromatography
N,O-bis(trimethylsilyl)trifluoroacetamide
N-heptafluorobutyrylproline

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Separation of beta adrenoceptor antagonist enantiomers by high resolution capillary gas chromatography. / Caccia, S.; Chiabrando, C.; De Ponte, P.; Fanelli, R.

In: Journal of Chromatographic Science, Vol. 16, No. 11, 1978, p. 543-546.

Research output: Contribution to journalArticle

@article{6a7a3815c98c4164ad07134922f9dff5,
title = "Separation of beta adrenoceptor antagonist enantiomers by high resolution capillary gas chromatography",
abstract = "The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N, O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.",
author = "S. Caccia and C. Chiabrando and {De Ponte}, P. and R. Fanelli",
year = "1978",
doi = "10.1093/chromsci/16.11.543",
language = "English",
volume = "16",
pages = "543--546",
journal = "Journal of Chromatographic Science",
issn = "0021-9665",
publisher = "Preston Publications",
number = "11",

}

TY - JOUR

T1 - Separation of beta adrenoceptor antagonist enantiomers by high resolution capillary gas chromatography

AU - Caccia, S.

AU - Chiabrando, C.

AU - De Ponte, P.

AU - Fanelli, R.

PY - 1978

Y1 - 1978

N2 - The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N, O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.

AB - The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N, O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018218037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018218037&partnerID=8YFLogxK

U2 - 10.1093/chromsci/16.11.543

DO - 10.1093/chromsci/16.11.543

M3 - Article

AN - SCOPUS:0018218037

VL - 16

SP - 543

EP - 546

JO - Journal of Chromatographic Science

JF - Journal of Chromatographic Science

SN - 0021-9665

IS - 11

ER -