TY - JOUR
T1 - Sepsis of Patients Infected by SARS-CoV-2
T2 - Real-World Experience From the International HOPE-COVID-19-Registry and Validation of HOPE Sepsis Score
AU - HOPE COVID-19 investigators
AU - Abumayyaleh, Mohammad
AU - Nuñez-Gil, Iván J.
AU - El-Battrawy, Ibrahim
AU - Estrada, Vicente
AU - Becerra-Muñoz, Víctor Manuel
AU - Uribarri, Aitor
AU - Fernández-Rozas, Inmaculada
AU - Feltes, Gisela
AU - Arroyo-Espliguero, Ramón
AU - Trabattoni, Daniela
AU - López Pais, Javier
AU - Pepe, Martino
AU - Romero, Rodolfo
AU - Ortega-Armas, María Elizabeth
AU - Bianco, Matteo
AU - Astrua, Thamar Capel
AU - D'Ascenzo, Fabrizio
AU - Fabregat-Andres, Oscar
AU - Ballester, Andrea
AU - Marín, Francisco
AU - Buonsenso, Danilo
AU - Sanchez-Gimenez, Raul
AU - Weiß, Christel
AU - Fernandez Perez, Cristina
AU - Fernández-Ortiz, Antonio
AU - Macaya, Carlos
AU - Akin, Ibrahim
N1 - Funding Information:
Cardiovascular Excellence SL for their essential support in the database and HOPE webpage.
Publisher Copyright:
© Copyright © 2021 Abumayyaleh, Nuñez-Gil, El-Battrawy, Estrada, Becerra-Muñoz, Uribarri, Fernández-Rozas, Feltes, Arroyo-Espliguero, Trabattoni, López Pais, Pepe, Romero, Ortega-Armas, Bianco, Astrua, D'Ascenzo, Fabregat-Andres, Ballester, Marín, Buonsenso, Sanchez-Gimenez, Weiß, Fernandez Perez, Fernández-Ortiz, Macaya, Akin and HOPE COVID-19 Investigators.
PY - 2021/10/14
Y1 - 2021/10/14
N2 - Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
AB - Background: Patients with sepsis with a concomitant coronavirus (COVID-19) infection are related to a high morbidity and mortality rate. We investigated a large cohort of patients with sepsis with a concomitant COVID-19, and we developed a risk score for the estimation of sepsis risk in COVID-19. Methods: We conducted a sub-analysis from the international Health Outcome Predictive Evaluation Registry for COVID-19 (HOPE-COVID-19-Registry, NCT04334291). Out of 5,837 patients with COVID-19, 624 patients were diagnosed with sepsis according to the Sepsis-3 International Consensus. Results: In multivariable analysis, the following risk factors were identified as independent predictors for developing sepsis: current smoking, tachypnoea (>22 breath per minute), hemoptysis, peripheral oxygen saturation (SpO2) <92%, blood pressure (BP) (systolic BP <90 mmHg and diastolic BP <60 mmHg), Glasgow Coma Scale (GCS) <15, elevated procalcitonin (PCT), elevated troponin I (TnI), and elevated creatinine >1.5 mg/dl. By assigning odds ratio (OR) weighted points to these variables, the following three risk categories were defined to develop sepsis during admission: low-risk group (probability of sepsis 3.1–11.8%); intermediate-risk group (24.8–53.8%); and high-risk-group (58.3–100%). A score of 1 was assigned to current smoking, tachypnoea, decreased SpO2, decreased BP, decreased GCS, elevated PCT, TnI, and creatinine, whereas a score of 2 was assigned to hemoptysis. Conclusions: The HOPE Sepsis Score including nine parameters is useful in identifying high-risk COVID-19 patients to develop sepsis. Sepsis in COVID-19 is associated with a high mortality rate.
KW - COVID-19
KW - outcome
KW - SARS-CoV-2
KW - score
KW - sepsis
UR - http://www.scopus.com/inward/record.url?scp=85118238496&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118238496&partnerID=8YFLogxK
U2 - 10.3389/fmed.2021.728102
DO - 10.3389/fmed.2021.728102
M3 - Article
AN - SCOPUS:85118238496
VL - 8
JO - Frontiers in Medicine
JF - Frontiers in Medicine
SN - 2296-858X
M1 - 728102
ER -