Septo-optic dysplasia and psychiatric disorders

Paola Bini, Lorenza Montalbetti, Pietro Tosca, Maria Teresa Ratti, Carla Uggetti, Arrigo Moglia, Alfredo Costa

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Septo-optic dysplasia, a variable combination of abnormalities of cerebral midline structures, is a clinically heterogeneous syndrome in which the midline defects may be implicated in psychiatric disturbances. OBJECTIVE: To describe a case of septo-optic dysplasia associated with depression and psychosis and to discuss the role of these developmental abnormalities in psychiatric disturbances. METHODS: The patient's clinico-anamnestic, neuroradiologic, neuropsychiatric, endocrinologic, ophthalmologic, and genetic profile was evaluated. CONCLUSIONS: Developmental abnormalities due to disruption of the complex neural network linking the septum pellucidum with other limbic structures may have been involved in the affective and psychotic disturbances observed in our patient.

Original languageEnglish
Pages (from-to)254-257
Number of pages4
JournalCognitive and Behavioral Neurology
Issue number4
Publication statusPublished - Dec 2008


  • Corpus callosum
  • Midline
  • Psychosis
  • Septo-optic dysplasia
  • Septum pellucidum

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology


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