Sequential administration of arginine and arginine plus GHRH to test somatotroph function in short children

J. Bellone, G. Aimaretti, S. Bellone, C. Baffoni, G. Corneli, C. Origlia, M. Cappa, E. Ghigo

Research output: Contribution to journalArticlepeer-review

Abstract

The hormonal diagnosis of GH deficiency in childhood is conventionally based on the GH response to at least two provocative stimuli. Among these, arginine (ARG) has long been considered a classical, centrally mediated stimulus of GH secretion. ARG is also able to potentiate the GH response to GHRH, likely inhibiting hypothalamic somatostatin; this combined test is one of the most potent to explore the maximal secretory capacity of somatotroph cells. Based on these premises, we verified whether the sequential administration of ARG and ARG+GHRH could be feasible as single step provocative test to evaluate the GH releasable pool in short children. To this goal, 48 normal short children (35 M and 13 F, 12.0±0.4 yr, PS 1: 255 II-IV: 23) underwent a test with ARG (0.5 g/kg iv from 0 to +30 min) followed by a coadministration of ARG (from +120 to 150 min) plus GHRH (1 μg/kg iv at +120 min). ARG alone elicited a clear GH response (mean peak vs baseline: 12.1±1.7 vs 2.0±0.4 μg/l, p

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalJournal of Endocrinological Investigation
Volume23
Issue number2
Publication statusPublished - 2000

Keywords

  • Arginine
  • GH
  • GHRH
  • Short stature

ASJC Scopus subject areas

  • Endocrinology

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