Sequential chemotherapy-radiotherapy in the treatment of advanced cervical carcinoma

F. Volterrani, S. Tana, L. Lozza, S. Marchini, F. Bianchi, B. Stefanon, G. De Palo

Research output: Contribution to journalArticlepeer-review

Abstract

Long term results of radiotherapy (RT) alone in the treatment of advanced cervical carcinomas (Stage II distal and III) are poor. Therefore, a combined therapeutic approach with neoadjuant chemotherapy (CT) and RT in a sequential scheme was started (CT for 3 cycles - RT - CT for 3 cycles). A cisplatinum (CDDP) plus bleomycin (BLM) regimen was given every three weeks for CT (CDDP 50 mg/m2 iv day 1, BLM 18 mg/m2 iv day 1 and 2) and megavoltage irradiation plus curietherapy boost for RT. From April '84 to August '85, 23 patients were treated. Three primary cycles of CDDP-BLM CT combination proved to be feasible and well tolerated. RT was not impaired by primary CT. On the contrary, the tolerance of CT following RT was poor. Complete plus partial (> 50%) remissions at the end of the primary CT were 52%, after following RT 78%, and at the end of entire treatment 78%. A total of 11 patients (48%) were NED with a median follow-up of 37.8 months (range 30-45).

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalCervix and the Lower Female Genital Tract
Volume8
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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