Sequential combination chemotherapy of advanced head and neck carcinoma: Re-evaluation of a highly effective regimen

A. Veronesi, L. Barzan, M. D. Magri, U. Tirelli, E. Galligioni, M. G. Trovò, S. Tumolo, R. Comoretto, E. Grigoletto

Research output: Contribution to journalArticle

Abstract

27 evaluable patients with advanced head and neck squamous carcinoma were treated with a polychemotherapeutic regimen described in 1975 by Price et al. Chemotherapy consisted of vincristine, adriamycin, bleomycin, methotrexate, 5-fluorouracil, hydroxyurea, 6-mercaptopurine and citrovorum factor administered sequentially. One complete remission, 4 partial remissions, 7 minor responses were obtained for a total of 12/27 (44%) objective responses. Toxicity was acceptable. The results obtained were not better than those observed with less complicated regimens administrable on an outpatient basis.

Original languageEnglish
Pages (from-to)277-279
Number of pages3
JournalStrahlentherapie
Volume157
Issue number4
Publication statusPublished - 1981

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6-Mercaptopurine
Hydroxyurea
Leucovorin
Bleomycin
Vincristine
Combination Drug Therapy
Methotrexate
Fluorouracil
Doxorubicin
Squamous Cell Carcinoma
Outpatients
Neck
Head
Carcinoma
Drug Therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Veronesi, A., Barzan, L., Magri, M. D., Tirelli, U., Galligioni, E., Trovò, M. G., ... Grigoletto, E. (1981). Sequential combination chemotherapy of advanced head and neck carcinoma: Re-evaluation of a highly effective regimen. Strahlentherapie, 157(4), 277-279.

Sequential combination chemotherapy of advanced head and neck carcinoma : Re-evaluation of a highly effective regimen. / Veronesi, A.; Barzan, L.; Magri, M. D.; Tirelli, U.; Galligioni, E.; Trovò, M. G.; Tumolo, S.; Comoretto, R.; Grigoletto, E.

In: Strahlentherapie, Vol. 157, No. 4, 1981, p. 277-279.

Research output: Contribution to journalArticle

Veronesi, A, Barzan, L, Magri, MD, Tirelli, U, Galligioni, E, Trovò, MG, Tumolo, S, Comoretto, R & Grigoletto, E 1981, 'Sequential combination chemotherapy of advanced head and neck carcinoma: Re-evaluation of a highly effective regimen', Strahlentherapie, vol. 157, no. 4, pp. 277-279.
Veronesi A, Barzan L, Magri MD, Tirelli U, Galligioni E, Trovò MG et al. Sequential combination chemotherapy of advanced head and neck carcinoma: Re-evaluation of a highly effective regimen. Strahlentherapie. 1981;157(4):277-279.
Veronesi, A. ; Barzan, L. ; Magri, M. D. ; Tirelli, U. ; Galligioni, E. ; Trovò, M. G. ; Tumolo, S. ; Comoretto, R. ; Grigoletto, E. / Sequential combination chemotherapy of advanced head and neck carcinoma : Re-evaluation of a highly effective regimen. In: Strahlentherapie. 1981 ; Vol. 157, No. 4. pp. 277-279.
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